Obstetrics and Gynecology, 73(2), 187-190
Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.
Eden, J. A., Place, J., Carter, G. D., Jones, J., Alaghband-Zadeh, J., & Pawson, M. E. (1989). The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. *Obstetrics and gynecology*, *73*(2), 187-190.
Eden JA, Place J, Carter GD, Jones J, Alaghband-Zadeh J, Pawson ME. The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. Obstet Gynecol. 1989;73(2):187-190.
Eden, J. A., et al. "The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume." *Obstetrics and gynecology*, vol. 73, no. 2, 1989, pp. 187-190.
Adult, Clomiphene/therapeutic Use, Endometrium/drug Effects, Estrogens/blood, Female, Follicle Stimulating Hormone/blood, Follicular Phase/drug Effects, Humans, Luteinizing Hormone/blood, Ovulation Induction, Testosterone/blood, Ultrasonography, Uterus/drug Effects, Estrogens, Clomiphene, Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone