Archives of Ophthalmology (Chicago, Ill. : 1960), 113(4), 482-484
Abstract
Objective To identify a distinctive constellation of persistent visual abnormalities secondary to treatment with clomiphene citrate.
Design Description of the clinical findings in three patients with visual disturbance secondary to clomiphene treatment.
Setting A neuro-ophthalmology referral center.
Patients Three women aged 32 to 36 years treated for infertility with clomiphene for 4 to 15 months.
Results All three patients experienced prolonged afterimages (palinopsia), shimmering of the peripheral field, and photophobia while undergoing treatment with clomiphene. The results of the neuro-ophthalmologic examination and electrophysiologic studies were normal in all three patients. Unlike previously reported cases, visual symptoms did not resolve on cessation of treatment. Patients remain symptomatic from 2 to 7 years after discontinuing treatment with the medication.
Conclusions Treatment with clomiphene can cause prolonged visual disturbance. Patients who develop such symptoms should be advised that continued administration may cause irreversible changes. Women with characteristic visual symptoms should be questioned about past use of clomiphene.
clomiphene citrate visual side effects, clomiphene visual disturbance palinopsia, persistent visual symptoms after clomiphene treatment, clomiphene citrate ocular toxicity infertility treatment, prolonged afterimages photophobia clomiphene, irreversible visual changes fertility medication, neuro-ophthalmologic complications ovulation induction drugs, Purvin clomiphene visual disturbance case series, clomiphene side effects shimmering peripheral vision, adverse effects clomiphene citrate long term
PMID 7710399 7710399 DOI 10.1001/archopht.1995.01100040102034 10.1001/archopht.1995.01100040102034
Keywords
Adult, Afterimage, Clomiphene/adverse Effects/therapeutic Use, Female, Humans, Infertility, Female/drug Therapy, Light, Sensation Disorders/chemically Induced, Vision Disorders/chemically Induced, Visual Fields, Clomiphene