Antiestrogenic effect of clomiphene citrate: correlation with serum estradiol concentrations

Maxson WS, Pittaway DE, Herbert CM, Garner CH, Wentz AC

Antiestrogenic effect of clomiphene citrate: correlation with serum estradiol concentrations

C M Herbert, W S Maxson, D E Pittaway, A C Wentz

Vanderbilt University Medical Center ROR
Atrium Health Wake Forest Baptist ROR

Fertility and Sterility, 42(3), 356-359

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Abstract

The antiestrogenic effect of clomiphene citrate (CC) on cervical mucus was evaluated in women receiving 150 mg CC daily for 5 days. Daily cervical mucus scores and serum estradiol (E2) concentrations were determined in control (n = 25) and CC (n = 24) cycles. E2 concentrations were significantly higher in the CC-treated women (mean +/- standard error of the mean, 1254 +/- 102 pg/ml versus 337 +/- 18 pg/ml, P less than 0.0001). Despite supraphysiologic E2 concentrations, however, cervical mucus scores were significantly reduced in the CC-treated group (P less than 0.01). These data indicate that CC exerts a direct suppressive effect on cervical mucus despite markedly increased E2 concentrations.

Topics

Infertility > Ovulation Induction > Clomiphene Citrate Side Effects Fertility Awareness > Cervical Mucus > Hormonal Influences Reproductive Endocrinology > Pharmacology > Anti-Estrogenic Effects

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Maxson, W. S., Pittaway, D. E., Herbert, C. M., Garner, C. H., & Wentz, A. C. (1984). Antiestrogenic effect of clomiphene citrate: correlation with serum estradiol concentrations. *Fertility and sterility*, *42*(3), 356-359.

Keywords

Adult, Cervix Mucus/drug Effects, Clomiphene/pharmacology, Estradiol/blood, Estrogen Antagonists, Female, Humans, Infertility, Female/drug Therapy, Menstruation, Ovulation, Estrogen Antagonists, Clomiphene, Estradiol

Antiestrogenic effect of clomiphene citrate: correlation with serum estradiol concentrations

Abstract

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