Vitamin D (Fertility Context)

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 31, 2026

Vitamin D (25-hydroxyvitamin D) is a fat-soluble prohormone that functions as a steroid hormone, regulating immune function, inflammation, and reproductive biology. Vitamin D receptors (VDRs) are expressed in the ovaries, endometrium, uterus, and spermatozoa, making adequate vitamin D status relevant across the full reproductive system.

Vitamin D deficiency is associated with reduced ovarian stimulation response in women with PCOS, lower live birth rates, impaired endometrial receptivity, and increased miscarriage risk. In RRM and NeoFertility practice, vitamin D status is routinely assessed as part of preconception evaluation. Optimization targets are individualized under clinical guidance rather than applied as a universal threshold.

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.