The risk of fetal anomalies as a result of progesterone therapy during pregnancy

Check JH, Rankin A, Teichman M

doi:10.1016/s0015-0282(16)49292-7

The risk of fetal anomalies as a result of progesterone therapy during pregnancy

J H Check, A Rankin, M Teichman

Cooper University Hospital ROR
Thomas Jefferson University ROR

Fertility and Sterility, 45(4), 575-577

DOI 10.1016/s0015-0282(16)49292-7 PMID 3956772

Abstract

The incidence of congenital anomalies in infants born to 382 women treated with P was noted. Only five anomalies occurred in the infants born to women who had taken P. This study supports the data of Rock et al. by demonstrating a similar low incidence of birth defects in a much larger series of patients who also took a much higher dosage of P. Similarly, because only 1 of 189 patients treated with both P and 17-OHP developed anomalies, the data supports the study by Katz et al., suggesting no increase in anomalies related to 17-OHP therapy.

Topics

Reproductive Endocrinology > Progesterone Therapy > Safety in Pregnancy Pregnancy > Medications in Pregnancy > Fetal Anomaly Risk Infertility > Luteal Phase Support > Progesterone Safety

progesterone therapy pregnancy fetal anomalies safety, congenital anomalies progesterone supplementation first trimester, 17-hydroxyprogesterone caproate birth defects risk, Check progesterone safety pregnancy congenital malformations, progesterone supplementation birth defect incidence large series, high dose progesterone pregnancy fetal safety outcomes, hormonal support pregnancy teratogenic risk progesterone, progesterone 17-OHP therapy pregnancy anomaly rate, luteal support progesterone safety fetal development, progesterone administration pregnancy congenital malformation incidence

PMID 3956772 3956772 DOI 10.1016/s0015-0282(16)49292-7 10.1016/s0015-0282(16)49292-7

Cite this article

Check, J. H., Rankin, A., & Teichman, M. (1986). The risk of fetal anomalies as a result of progesterone therapy during pregnancy. *Fertility and sterility*, *45*(4), 575-577. https://doi.org/10.1016/s0015-0282(16)49292-7

Keywords

17-alpha-Hydroxyprogesterone, Abnormalities, Drug-Induced/epidemiology, Abortion, Spontaneous/prevention & Control, Drug Therapy, Combination, Female, Humans, Hydroxyprogesterones/administration & Dosage/adverse Effects, Infant, Newborn, Injections, Intramuscular, Pregnancy, Pregnancy Trimester, First, Progesterone/administration & Dosage/adverse Effects, Retrospective Studies, Risk, Suppositories, Surveys and Questionnaires, Vagina, Hydroxyprogesterones, Suppositories, Progesterone, 17-alpha-Hydroxyprogesterone

The risk of fetal anomalies as a result of progesterone therapy during pregnancy

Abstract

Topics

Cite this article

Keywords

Related articles

Neonatal characteristics of children conceived with in vitro fertilization or intrauterine insemination compared with sibling births from unassisted conceptions

Disordered eating behaviors during adolescence and risk of endometriosis: a prospective cohort study

"Reply of the authors: ""Response to ""The illusion of reproductive choice: how restorative reproductive medicine violates informed consent for infertility treatment"""""

Reply of the authors: "Response to "The illusion of reproductive choice: how restorative reproductive medicine violates reproductive autonomy and informed consent"" by Frank-Herrmann et al