0

The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume

Eden JA et al., 1989

Obstetrics and gynecology, 73(2), 187-190

PMID 2492092 Source

Abstract

Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.

Topics

Infertility > Female Factor > Ovulatory DysfunctionReproductive Endocrinology > Estrogen > Clinical EffectsDiagnostics > Ultrasound > Endometrial AssessmentMenstrual Cycle > Physiology > Follicular Phase
clomiphene citrate endometrial thickness, clomid anti-estrogenic effects endometrium, ovulation induction uterine lining thinning, clomiphene uterine volume suppression, follicular phase endometrial growth, clomiphene side effects endometrium, why does clomid thin uterine lining, ovulation induction endometrial suppression, clomiphene estradiol paradox, ultrasound follicular endometrial monitoring, clomiphene versus natural cycle endometrium

Cite this article

Eden, J. A., Place, J., Carter, G. D., Jones, J., Alaghband-Zadeh, J., & Pawson, M. E. (1989). The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. *Obstetrics and gynecology*, *73*(2), 187-190.

Keywords

Adult, Clomiphene, Endometrium, Estrogens, Female, Follicle Stimulating Hormone, Follicular Phase, Humans, Luteinizing Hormone, Ovulation Induction, Testosterone, Ultrasonography, Uterus

Related articles