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The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate

Yagel S et al., 1992

Fertility and sterility, 57(1), 33-36

DOI 10.1016/s0015-0282(16)54772-4 PMID 1730327 Source

Abstract

Objective

To assess the deleterious effect of clomiphene citrate (CC) on the development of the endometrium and its improvement by the addition of ethinyl estradiol (E2). PARTICIPATING

Patients

Infertility-treated patients, monitored for induction of ovulation or timing of insemination (control group).

Design

We studied four groups of women during an ovulatory cycle with various treatment schedules. Group 1: untreated patients; group 2: patients treated by CC; group 3: patients treated by CC + ethinyl E2; group 4: patients treated by human menopausal gonadotropin. Follow-up of the patients was done by vaginal ultrasonography and measurements of blood E2.

Results

In the group treated by CC, both endometrial thickness and uterine volume growth during the follicular phase were lower as compared with untreated controls and menotropin-treated patients. The addition of ethinyl E2 to these patients reversed this deleterious effect of CC without interfering with ovulation.

Conclusion

Ethinyl E2 may reverse the deleterious effect of CC on endometrial development during the follicular phase.

Topics

Infertility > Female Factor > Ovulatory DysfunctionReproductive Endocrinology > Ovulation > InductionDiagnostics > Ultrasound > Endometrial AssessmentReproductive Endocrinology > Estrogen > Clinical Effects
clomiphene citrate thin endometrium, clomid endometrial thickness problem, ethinyl estradiol endometrial development, ovulation induction endometrium, clomiphene adverse effects endometrium treatment, uterine volume follicular phase monitoring, improving endometrial lining during ovulation induction, clomid side effects endometrial thickness, ultrasound endometrium clomiphene, estrogen supplementation clomiphene cycles, ovulation induction endometrial response, vaginal ultrasound follicular monitoring endometrium

Cite this article

Yagel, S., Ben-Chetrit, A., Anteby, E., Zacut, D., Hochner-Celnikier, D., & Ron, M. (1992). The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate. *Fertility and sterility*, *57*(1), 33-36. https://doi.org/10.1016/s0015-0282(16)54772-4

Keywords

Adult, Clomiphene, Drug Therapy, Combination, Endometrium, Estradiol, Ethinyl Estradiol, Female, Humans, Infertility, Menotropins, Ovulation, Ovulation Induction, Uterus

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