Plasma progesterone, 17-hydroxyprogesterone, 20alpha hydroxypregn-4-en-3-one levels were determined twice weekly up to 16 weeks gestation, where possible, in a twin pregnancy, in two patients who aborted spontaneously and in three patients who were treated with 'progesterone supplements' because of abnormal vaginal cytology. There was no correlation between vaginal smears and the plasms hormone levels and there was no evidence to suggest that progesterone supplements influenced clinical outcome. Compared with normal mean values the only difference was a significantly rise in progesterone and 20alpha hydroxypregn-4-en-3-one levels in the twin pregnancy after the 12th week and a precipitate fall in all hormone levels just prior to abortion. Plasma hormone levels could not be used to predict outcome.
plasma progesterone levels early abnormal pregnancy, 17-hydroxyprogesterone secretion patterns spontaneous abortion, progesterone supplementation abnormal vaginal cytology pregnancy, Harrison progesterone early pregnancy hormone monitoring, hormone levels predicting pregnancy outcome first trimester, 20alpha hydroxypregn-4-en-3-one early pregnancy, twin pregnancy progesterone levels comparison, serial hormone measurements threatened miscarriage, progesterone supplementation clinical outcome pregnancy loss, plasma steroid hormone patterns early gestation abnormal pregnancy
PMID 737159 737159 DOI 10.1111/j.1471-0528.1978.tb15855.x 10.1111/j.1471-0528.1978.tb15855.x
Cite this article
Harrison, R. F., Youssefnejadian, E., Brodovcky, H., Johnson, M., & Dewhurst, J. (1978). Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy. *British journal of obstetrics and gynaecology*, *85*(12), 927-932. https://doi.org/10.1111/j.1471-0528.1978.tb15855.x
Harrison RF, Youssefnejadian E, Brodovcky H, Johnson M, Dewhurst J. Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy. Br J Obstet Gynaecol. 1978;85(12):927-932. doi:10.1111/j.1471-0528.1978.tb15855.x
Harrison, R. F., et al. "Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy." *British journal of obstetrics and gynaecology*, vol. 85, no. 12, 1978, pp. 927-932.
Baud O et al., 1999British Journal of Obstetrics and Gynaecology
OBJECTIVES: To test the association between cytokine levels in the amniotic fluid and (i) the vascular invasion phase of intrauterine infection, (ii) the occurrence of periventricular leukomalacia; to...
Thorogood M et al., 1999British Journal of Obstetrics and Gynaecology
Objective: To examine the risk of multiple sclerosis in users of combined oral contraceptives.
Design: Cohort study conducted between 1968 and 1996 using diagnostic data supplied by general practition...
Karjalainen A et al., 1997British Journal of Obstetrics and Gynaecology
OBJECTIVE: To investigate changes in plasma lipid and lipoprotein levels induced by peroral oestrogen replacement and transdermal oestradiol gel therapy.
DESIGN: The effects of peroral oestradiol val...