To investigate changes in plasma lipid and lipoprotein levels induced by peroral oestrogen replacement and transdermal oestradiol gel therapy.
Design
The effects of peroral oestradiol valerate tablets (2 mg) and placebo gel were compared with 1g transdermal oestradiol gel (1mg oestradiol) and placebo tablets in a randomised, double-blind, double-dummy study for 6 months.
Setting
Department of Internal Medicine, University of Oulu and Oulu Deaconess Institute, Oulu, Finland.
Population
Seventy-nine hysterectomised, postmenopausal women, 39 women in the peroral oestrogen group and 40 in the gel group.
Main Outcome Measures
Cholesterol and triglycerides in total plasma and in various lipoprotein fractions, and sex hormones.
Results
In the peroral oestrogen group total and LDL cholesterol were decreased and HDL cholesterol and triglycerides were increased. In the oestradiol gel group plasma total, LDL and VLDL cholesterol and the ratio of LDL/HDL cholesterol were significantly decreased, but no change in HDL cholesterol and triglycerides was observed. Overall the decrease in LDL levels was correlated with the increase in oestrogen levels.
Conclusions
Both peroral and transdermal replacement therapy had beneficial effects on plasma lipids by lowering total and LDL cholesterol and LDL/HDL cholesterol ratio. These changes seem to be associated with changes in oestrogen levels.
oral estrogen versus transdermal estradiol gel lipid effects, peroral estradiol valerate LDL cholesterol postmenopausal women, transdermal estradiol gel triglycerides HDL cholesterol, hormone replacement therapy lipid lipoprotein changes menopause, estrogen route of administration metabolic effects randomized trial, postmenopausal estrogen therapy cardiovascular lipid profile, double-blind estrogen replacement LDL HDL cholesterol ratio, hysterectomised women estrogen replacement VLDL cholesterol, transdermal versus oral estrogen metabolic outcomes, estradiol gel placebo controlled lipid lowering postmenopausal
PMID 9389782 9389782 DOI 10.1111/j.1471-0528.1997.tb11566.x 10.1111/j.1471-0528.1997.tb11566.x
Cite this article
Karjalainen, A., Heikkinen, J., Savolainen, M. J., Bäckström, A. C., Salinto, M., & Kesäniemi, Y. A. (1997). Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy. *British journal of obstetrics and gynaecology*, *104 Suppl 16*(s16), 38-43. https://doi.org/10.1111/j.1471-0528.1997.tb11566.x
Karjalainen A, Heikkinen J, Savolainen MJ, Bäckström AC, Salinto M, Kesäniemi YA. Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy. Br J Obstet Gynaecol. 1997;104 Suppl 16(s16):38-43. doi:10.1111/j.1471-0528.1997.tb11566.x
Karjalainen, Anna, et al. "Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy." *British journal of obstetrics and gynaecology*, vol. 104 Suppl 16, no. s16, 1997, pp. 38-43.
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