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Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Michaelis J et al., 1983

Teratology, 27(1), 57-64

DOI 10.1002/tera.1420270109 PMID 6845218 Source

Abstract

From 1964 to 1976, a cohort study was performed in West Germany to study the possible influence of various factors on pregnancy and child development. Results of the evaluation of 13,643 pregnancies are given with respect to possible teratogenetic effects of antiemetic drugs and sex hormones administered in early pregnancy. There was no evidence of an increased risk of major malformations following the intake of certain antiemetic drugs and progesterone. Also, the use of a hormonal pregnancy test was not significantly associated with an increase of major malformations.

Topics

Pregnancy > Outcomes > ComplicationsReproductive Endocrinology > Progesterone > Clinical EffectsGeneral OB/GYN > Clinical Practice > Standards
progesterone early pregnancy safety, drug exposure first trimester, hormonal pregnancy test birth defects, antiemetic medications pregnancy, teratogenicity progesterone supplementation, congenital malformations hormone use, progesterone drug safety pregnancy, first trimester medication risks, pregnancy test hormones malformations, drug induced birth defects study

Cite this article

Michaelis, J., Michaelis, H., Glück, E., & Koller, S. (1983). Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations. *Teratology*, *27*(1), 57-64. https://doi.org/10.1002/tera.1420270109

Keywords

Abnormalities, Drug-Induced, Antiemetics, Dicyclomine, Doxylamine, Drug Combinations, Estradiol, Female, Germany, West, Humans, Pregnancy, Progesterone, Prospective Studies, Pyridoxine, Time Factors, Pyridoxine Drug Combination, Estradiol Benzoate, Progesterone Drug Combination

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