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Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-controlled clinical trial

Vitale SG et al., 2020

Vitale SG, Corrado F, Caruso S, Giunta L, Cianci A, D'Anna R, Di Benedetto A

International journal of food sciences and nutrition, 72(5), 670-679, 2021

Source DOI PubMed

Abstract

This study aims to evaluate the effects of myo-inositol supplementation on gestational diabetes mellitus (GDM) rates and body water distribution in overweight non-obese women. 223 overweight non-obese women pregnant were randomly assigned to the treatment group (2 g of myo-inositol plus 200 µg of folic acid) or to the placebo one (200 µg of folic acid). The treatment lasted until three weeks after delivery. A tetrapolar impedance analyser was used to study body composition. The incidence of GDM was significantly reduced in the myo-inositol group compared with the placebo group. There was a significant increase in TBW, ECW and ICW values in the placebo group compared to the myo-inositol group. We have recorded a significant reduction in the overall incidence of pregnancy-induced hypertension in the myo-inositol group compared with the placebo group. Our results demonstrate the effectiveness of myo-inositol supplementation in preventing GDM in overweight non-obese pregnant women.

Topics

Pregnancy > Outcomes > ComplicationsReproductive Endocrinology > Progesterone > Clinical EffectsGeneral OB/GYN > Clinical Practice > Guidelines
myo-inositol gestational diabetes prevention, inositol supplement pregnancy, preventing gestational diabetes overweight women, body composition pregnancy supplementation, pregnancy-induced hypertension prevention, randomized trial inositol gdm, bioelectrical impedance pregnancy, folic acid inositol pregnancy, metabolic outcomes pregnancy supplementation, neonatal outcomes maternal inositol

Cite this article

Vitale, S. G., Corrado, F., Caruso, S., Giunta, L., Cianci, A., D'Anna, R., & Di Benedetto, A. (2020). Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-controlled clinical trial. *International journal of food sciences and nutrition*, *72*(5), 670-679. https://doi.org/10.1080/09637486.2020.1852191

Keywords

Diabetes, Gestational, Dietary Supplements, Electric Impedance, Female, Folic Acid, Humans, Infant, Newborn, Inositol, Overweight, Pregnancy, Gestational Diabetes Mellitus, Body Water, Myo-inositol, Outcomes

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