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Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Andrew FD et al., 1977

Teratology, 15(1), 25-32

DOI 10.1002/tera.1420150104 PMID 841480 Source

Abstract

Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.

Topics

Reproductive Endocrinology > Progesterone > Clinical EffectsPregnancy > Outcomes > Complications
medroxyprogesterone acetate teratogenicity, synthetic progestin pregnancy safety, depo-provera prenatal toxicity, progestin-induced birth defects animal models, cleft palate progestin exposure, mpa fetal malformations, synthetic progesterone safety pregnancy, hormonal contraception pregnancy risks, progestin teratology studies, animal toxicity synthetic hormones pregnancy

Cite this article

Andrew, F. D., & Staples, R. E. (1977). Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice. *Teratology*, *15*(1), 25-32. https://doi.org/10.1002/tera.1420150104

Keywords

Abnormalities, Drug-Induced, Animals, Body Weight, Cleft Palate, Dose-Response Relationship, Drug, Female, Fetal Death, Gestational Age, Maternal-Fetal Exchange, Medroxyprogesterone, Mice, Pregnancy, Rabbits, Rats

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