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Predictive value of C-reactive protein in serum of maternal and cord blood in cases with premature rupture of membranes

Awara AM et al., 1992

Egyptian medical journal, 9(2), 31-37

PMID 12285340 Source

Abstract

Physicians compared clinical history, examination, and laboratory data on 10 pregnant women at various gestational ages with intact membranes till labor began (controls) with data on 25 pregnant women also at various gestational ages who experienced premature rupture of membranes (PROM) (cases) to determine the value of C-reactive protein (CRP) in maternal and cord blood as a predictor of chorioamnionitis in women with PROM. 32% of cases had clinical chorioamnionitis and 44% histopathological chorioamnionitis. The maternal serum level of CRP in cases with and without chorioamnionitis at delivery was statistically higher than that of the controls (45.82 CRP mg/L and 9.71 CRP mg/L vs. 6.6 CRP mg/l; P.05). Further the CRP level in cord blood of cases with chorioamnionitis also stood much higher than that of the controls (p.001). In addition, the total leukocytic count (TLC) for cases with chorioamnionitis at delivery was much higher than it was for the control group at delivery (12,510 TLC/cubic mm vs. 18,231 TLC/cubic mm; p.05). A significant difference also existed between the temperature of the cases with chorioamnionitis and that of the controls (37.11 degrees Celsius vs. 63.97 degrees Celsius; p.05). Sensitivity and specificity tests showed that CRP 24 mg/L was the most reliable predictor of chorioamnionitis (100% and 93.3% respectively) followed by TLC (77.8% and 92.8% respectively) then temperature (55.6% and 78.6% respectively). Thus CRP can be used to predict premature delivery and simultaneously reduces unnecessary premature delivery of many PROM cases which occur due to fear of developing infections in both the mother and the fetus.

Topics

Pregnancy > Complications > InfectionPregnancy > Preterm Birth > Risk Factors
c-reactive protein premature rupture membranes, CRP predictor chorioamnionitis, PROM infection markers, maternal cord blood inflammatory markers, premature rupture membranes diagnosis, chorioamnionitis prediction biomarkers, preterm delivery infection risk, serum CRP pregnancy complications

Cite this article

Awara, A. M., Marei, S. K., Elghorab, N. M., Elnewahy, M. A., & Aboulenin, A. A. (1992). Predictive value of C-reactive protein in serum of maternal and cord blood in cases with premature rupture of membranes. *Egyptian medical journal*, *9*(2), 31-37.

Keywords

Adolescent, Africa, Northern, Age Factors, Biology, Blood, Blood Proteins, Case-Control Studies, Cervix Uteri, Clinical Laboratory Techniques, Demography, Developing Countries, Diagnosis, Disease, Egypt, Extraembryonic Membranes, Fetus, Genitalia, Female, Gestational Age, Hematologic Tests, Histology, Infant, Premature, Infections, Methods, Middle East, Physiology, Population, Population Characteristics, Pregnancy, Pregnancy Complications, Reproduction, Research, Urogenital System, Uterus, Arab Countries, Bacterial And Fungal Diseases, Case Control Studies, Cervix, Demographic Factors, Diseases, Examinations And Diagnoses, Fetal Membranes, Hematological Effects, Hemic System, Laboratory Examinations And Diagnoses, Laboratory Procedures, Mediterranean Countries, Methodological Studies, Northern Africa, Research Methodology, Serum Protein Effects, Studies, Youth

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