Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the distribution of locatio...
Estradiol, an estrogen steroid hormone, serves as the dominant female hormone and its levels fluctuate during lifetime. In women, after the menopause, all estrogens and almost all androgens are locall...
Nijsten K et al.2021Acta obstetricia et gynecologica Scandinavica
INTRODUCTION: Hyperemesis gravidarum (HG) complicates 1% of pregnancies and has a major impact on maternal quality of life and well-being. We know very little about HG's long-term impact after an affe...
Chang WH et al.2021Science of The Total Environment
Phthalate esters (PAEs) are one of the most widely used plasticizers in polymer products and humans are increasingly exposed to them. The constant exposure to PAEs-contained products has raised some c...
The 2019 Assisted Reproductive Technology (ART) Fertility Clinic and National Summary Report, prepared by the Centers for Disease Control and Prevention (CDC) under the Fertility Clinic Success Rate a...
Marcu I et al.2021
Open Access
Translational Andrology and Urology
Background: Glomerulations are not specific for interstitial cystitis/bladder pain syndrome (IC/BPS). Controversy exists about whether cystoscopic findings differ between patients with and without low...
In recent years, the term 'medical gaslighting' and accompanying accounts of self-identified women experiencing invalidation, dismissal and inadequate care have proliferated in the media. Gaslighting ...
Gender Bias in MedicineMedical GaslightingStructural Healthcare Barriers
Morssinkhof MWL et al.2021
Open Access
Psychoneuroendocrinology
Background: Worldwide, oral contraceptive (OC) use is a very common form of birth control, although it has been associated with symptoms of depression and insomnia. Insomnia is a risk factor for major...
Depression and MoodSleep and InsomniaLongitudinal Cohort Study
Martínez Leo EE et al.2021Nutrition (Burbank, Los Angeles County, Calif.)
In recent years, consumption of ultra-processed food around the world has been increasing. The nutritional profile of an ultra-processed diet is associated with the development of cellular alterations...
Ultra-Processed Diet EffectsOxidative Stress and Immune Tolerance
People living with HIV are ageing, and a growing number of women living with HIV are entering menopause. Women living with HIV commonly have bothersome vasomotor symptoms and onset of menopause at ear...
Hormone Therapy in HIVHIV-Associated Bone LossVasomotor Symptoms Management
Introduction: Women living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a comb...
Peebles K et al.2021Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
BACKGROUND: Limited evidence suggests that the nonhormonal contraceptive copper intrauterine device (Cu-IUD) may increase bacterial vaginosis (BV) risk, possibly due to increased volume and duration o...
OBJECTIVE: To study childbirth and the risk of miscarriage and infertility among women who have received a diagnosis of type 2 diabetes before the start of their reproductive journey.
DESIGN: Registe...
Alonso Pacheco L et al.2021Archives of Gynecology and Obstetrics
PURPOSE: To investigate and propose a new simple tridimensional (3D) ultrasonographic method to diagnose a T-shaped uterus (Class U1a).
METHODS: A multicenter non-experimental case-control diagnostic...
3D Ultrasound Uterine AnomaliesT-Shaped Uterus DiagnosisCase-Control Diagnostic Accuracy
Bliuc D et al.2021Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Cognitive decline and osteoporosis often coexist and some evidence suggests a causal link. However, there are no data on the longitudinal relationship between cognitive decline, bone loss and fracture...
Cognitive Decline and Bone LossProspective Cohort StudiesLongitudinal Population-Based Study
OBJECTIVE: This study investigated the effects of Tartrazine and Erythrosine (T+E) on the reproductive hormones and expression of some pro-inflammatory cytokines and testicular genes in testis of male...
Anderl C et al.2021
Open Access
Journal of Child Psychology and Psychiatry, and Allied Disciplines
Background: Because of the widespread use of oral contraceptives (OCs) and the devastating effects of depression both on an individual and a societal level, it is crucial to understand the nature of t...
Stanford JB et al.2021
Open Access
BMC Pregnancy and Childbirth
Background: Restorative reproductive medicine (RRM) seeks to identify and correct underlying causes and factors contributing to infertility and reproductive dysfunction. Many components of RRM are hig...
Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epith...
Turner JV2021The journal of obstetrics and gynaecology research
AIM: Simplified contraceptive method-efficacy and/or typical-use effectiveness rates are commonly used for direct comparison of the various contraceptive methods. Use of such effectiveness rates in th...
OBJECTIVE: Evaluation of vitamin D supplementation on ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency.
METHODS: The study is a before-and-after intervention study th...
Alvarez-Mon MA et al.2021
Open Access
Frontiers in Public Health
Background: Media outlets influence social attitudes toward health habits. The analysis of tweets has become a tool for health researchers.
Objective: The objective of this study was to investigate t...
Buskmiller C et al.2021Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
Objective: Preoperative short cervical length (CL) remains a major risk factor for preterm birth after laser surgery for twin-twin transfusion syndrome (TTTS), but the optimal intervention to prolong ...
Tenório MCDS et al.2021Antioxidants (Basel, Switzerland)
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon and dependent on the ...
Shieh A et al.2021The Journal of clinical endocrinology and metabolism
CONTEXT: Bone mineral density (BMD) decreases rapidly during menopause transition (MT), and continues to decline in postmenopause.
OBJECTIVE: This work aims to examine whether faster BMD loss during ...
Zhu TY et al.2021Journal of medical Internet research
BACKGROUND: As a daily point measurement, basal body temperature (BBT) might not be able to capture the temperature shift in the menstrual cycle because a single temperature measurement is present on ...
Ramasamy R et al.2021Environmental Science and Pollution Research
Microfiber pollution is one of the recent threats to sustainability. Due to the increased use of synthetic textiles, microplastic fiber release to the environment has increased exponentially. This rev...
This paper looks at the ethics of assisted reproductive technology (ART) from the perspective of the Catholic Church. The three criteria of evaluation of the ethics of ART are the right to life and ph...
Catholic BioethicsEthical Alternative to ARTNaProTECHNOLOGY
CONTEXT: Phthalate exposure is associated with altered reproductive function, but little is known about associations of phthalate exposure with risk of hot flashes.
OBJECTIVE: To investigate associat...
Smith SJ et al.2021Advances in nutrition (Bethesda, Md.)
Testosterone concentrations in males tend to decline with advancing age. Low testosterone, also known as androgen deficiency (AD), is associated with an increased risk of morbidity and mortality. Curr...
# Fertility treatment 2019: trends and figures
UK statistics for IVF and DI treatment, storage, and donation
Published: May 2021
Fertility trends is our annual statistical release. The key findings ar...
IVF Success RatesPopulation StatisticsNational Registry Data
Phthalates are a series of widely used chemicals that demonstrate to be endocrine disruptors and are detrimental to human health. Phthalates can be found in most products that have contact with plasti...
Najmabadi S et al.2021Human Reproduction (Oxford, England)
STUDY QUESTION: What is the normal range of cervical mucus patterns and number of days with high or moderate day-specific probability of pregnancy (if intercourse occurs on a specific day) based on ce...
Objective: To synthesize the literature on fertility knowledge and fertility-awareness among women seeking pregnancy.
Data Sources: The search terms "fertility-awareness OR fertility knowledge AND wo...
Jimenez MP et al.2021
Open Access
International Journal of Environmental Research and Public Health
There is extensive empirical literature on the association between exposure to nature and health. In this narrative review, we discuss the strength of evidence from recent (i.e., the last decade) expe...
Ahn SH et al.2021
Open Access
Frontiers in Endocrinology
The aim of this study was to determine predictive factors for pregnancy and assess the cumulative pregnancy rate (CPR) and live birth rate (CLBR) in subfertile couples undergoing timed intercourse (TI...
Jordan SJ et al.2021International journal of cancer
A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations bet...
Practice Committee of the American Society for Reproductive Medicine2021Fertility and Sterility
This document reviews surgical options for reparative tubal surgery and the factors that must be considered when deciding between surgical repair and in vitro fertilization. This document replaces the...
Burning mouth syndrome is a chronic pain condition characterized by a burning sensation of the oropharynx. The pathophysiology of burning mouth syndrome includes peripheral and central sensitization. ...
Hormonal contraceptives have been on the market for over fifty years and, while their formulations have changed, the basic mechanism of action has remained the same. During this time, numerous studies...
Background: Breast cancer is the leading cause of cancer death among Hispanic women. The aim of our study was to estimate cardiovascular disease (CVD) risk among Hispanic and non-Hispanic White (NHW) ...
Qeadan F et al.2021
Open Access
BMC Pregnancy and Childbirth
BACKGROUND: Pregnant women are potentially a high-risk population during infectious disease outbreaks such as COVID-19, because of physiologic immune suppression in pregnancy. However, data on the mor...
Background: Infertility is a significant problem with multiple causes and a corresponding array of therapeutic options. In an era of increasing assisted reproductive treatments, few studies examine th...
Saleh B et al.2021Breast Cancer Research and Treatment
Purpose: Herein, our purpose was to calculate the 5-year and lifetime risk of breast cancer and to assess new breast cancer potential contributors among Egyptian women utilizing the modified Gail mode...
Cancer Risk AssessmentBreast Cancer RiskCross-Sectional Studies
OBJECTIVE: To determine whether discontinuing oxytocin stimulation in the active phase of induced labour is associated with lower caesarean section rates.
DESIGN: International multicentre, double bl...
Objective: Donor demise after laser surgery for twin-twin transfusion syndrome (TTTS) is well-characterized, but recipient demise is not, nor is neonatal death. This study aims to characterize factors...
Twin-Twin Transfusion SyndromeFetal and Neonatal MortalityRecursive Partitioning
Lucaccioni L et al.2021
Open Access
International Journal of Molecular Sciences
Phthalates, as other endocrine disrupting chemicals (EDCs), may alter the homeostasis and the action of hormones and signaling molecules, causing adverse health outcomes. This is true especially for i...
Harjee R et al.2021Journal of Minimally Invasive Gynecology
Objective: To evaluate the efficacy of surgical management for isthmoceles in patients presenting with secondary infertility.
Data Sources: A systematic search was performed in MEDLINE, EMBASE, and C...