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Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis

Fishman A et al., 1996

European journal of obstetrics, gynecology, and reproductive biology, 70(1), 69-74

DOI 10.1016/s0301-2115(96)02563-8 PMID 9031923 Source

Abstract

Background

Malignant transformation to endometriosis is a well documented phenomenon that occurs most commonly in the ovaries with cancer arising in extra-ovarian endometriosis being a rare event.

Methods

A retrospective clinical-pathological evaluation of eleven cases with malignant tumors arising in endometriosis was performed to evaluate the prognostic impact of various factors. Nuclear DNA content (ploidy) was assessed through flow cytometric study.

Results

Ovarian origin was identified in eight cases and three were associated with extra-ovarian endometriosis. Histologic type was endometrioid carcinoma in ten patients. The eleventh case had high grade endometrial stromal sarcoma. All tumors were diploid with no relation to stage, grade, or clinical outcome. The S-phase fraction (SPF) was analyzed in nine patients and no correlation could be demonstrated with any histologic parameters or clinical outcome.

Conclusions

The DNA content seems to have no association with the classical prognostic parameters in these cases.

Topics

Endometriosis > Pathophysiology > MechanismsGeneral OB/GYN > Epidemiology > Prevalence
malignant transformation endometriosis, endometriosis cancer risk ovarian, endometrioid carcinoma arising from endometriosis, endometriosis malignancy prognosis, ovarian cancer endometriosis-associated, endometrial stromal sarcoma endometriosis, flow cytometry endometriosis cancer, extra-ovarian endometriosis malignancy, dna ploidy endometriosis carcinoma, endometriosis oncologic complications

Cite this article

Fishman, A., Demirel, D., Laucirica, R., Ramzy, I., Klima, T., Lyzak, J., & Kaplan, A. L. (1996). Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis. *European journal of obstetrics, gynecology, and reproductive biology*, *70*(1), 69-74. https://doi.org/10.1016/s0301-2115(96)02563-8

Keywords

Adult, Aged, Carcinoma, Endometrioid, Cell Transformation, Neoplastic, DNA, Endometrial Neoplasms, Endometriosis, Female, Flow Cytometry, Genital Neoplasms, Humans, Middle Aged, Ovarian Neoplasms, Pelvic Neoplasms, Ploidies, Prognosis, Retrospective Studies, Sarcoma, Vaginal Neoplasms

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