Some randomized studies have suggested a significant beneficial effect of 17-hydroxyprogesterone caproate in the prevention of preterm labor [1, 2], The therapy in both studies was initiated at approximately 12-16 weeks and continued until labor.
We considered the possibility that a deficient proges terone effect during the first trimester may lead to a higher rate of preterm deliveries. A retrospective study was thus performed comparing the incidence of preterm versus full-term pregnancies in women with luteal phase defects who were either treated or not treated with proges terone supplementation during the first trimester.
PMID 1612531 1612531 DOI 10.1159/000294877 10.1159/000294877
Cite this article
Check, J. H., Lee, G., Epstein, R., & Vetter, B. (1992). Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report. *Gynecologic and obstetric investigation*, *33*(3), 183-184. https://doi.org/10.1159/000294877
Check JH, Lee G, Epstein R, Vetter B. Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report. Gynecol Obstet Invest. 1992;33(3):183-184. doi:10.1159/000294877
Check, J. H., et al. "Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report." *Gynecologic and obstetric investigation*, vol. 33, no. 3, 1992, pp. 183-184.
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