Gynecologic and Obstetric Investigation, 50 Suppl 1(Suppl. 1), 39-43
We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. Frequent LOH was observed on chromosome 6q (60.0%) and chromosome 10q (40.0%) in ovarian atypical endometriosis, but no PTEN mutations were observed. These findings support the hypothesis that endometrioid and clear cell ovarian carcinomas may arise through malignant transformation of endometriotic lesions.
Obata, K., & Hoshiai, H. (2000). Common genetic changes between endometriosis and ovarian cancer. *Gynecologic and obstetric investigation*, *50 Suppl 1*(Suppl. 1), 39-43. https://doi.org/10.1159/000052877
Obata K, Hoshiai H. Common genetic changes between endometriosis and ovarian cancer. Gynecol Obstet Invest. 2000;50 Suppl 1(Suppl. 1):39-43. doi:10.1159/000052877
Obata, Koshiro, and Hiroshi Hoshiai. "Common genetic changes between endometriosis and ovarian cancer." *Gynecologic and obstetric investigation*, vol. 50 Suppl 1, no. Suppl. 1, 2000, pp. 39-43.
Adenocarcinoma, Clear Cell/genetics/pathology, Carcinoma, Endometrioid/genetics/pathology, DNA Mutational Analysis, Endometriosis/genetics/pathology, Female, Genes, Tumor Suppressor, Humans, Loss of Heterozygosity/genetics, Mutation, Ovarian Neoplasms/genetics/pathology, PTEN Phosphohydrolase, Phosphoric Monoester Hydrolases/genetics, Sensitivity and Specificity, Tumor Suppressor Proteins, Tumor Suppressor Proteins, Phosphoric Monoester Hydrolases, PTEN Phosphohydrolase, PTEN Protein, Human