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Incidence of endometriosis by study population and diagnostic method: the ENDO study

Germaine M Buck Louis, Zhian Chen, Linda C Giudice, C Matthew Peterson, Joseph B Stanford, Rajeshwari Sundaram, Michael W Varner, Mary Croughan, Ann C. Trumble, ENDO Study Working Group, Victor Y Fujimoto, Mary L Hediger

Author affiliations (6)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development ROR
  • Zhejiang Chinese Medical University ROR
  • Stanford Medicine ROR
  • University of Utah ROR
  • National Institutes of Health ROR
  • University of California, San Francisco ROR

Fertility and Sterility, 96(2), 360-365, 2011

DOI 10.1016/j.fertnstert.2011.05.087 PMID 21719000

Abstract

Objective

To estimate the incidence of endometriosis in an operative cohort of women seeking clinical care and in a matched population cohort to delineate more fully the scope and magnitude of endometriosis in the context of and beyond clinical care.

Design

Matched-exposure cohort design.

Setting

Surgical centers in the Salt Lake City, Utah, and San Francisco, California, areas. PATIENT(S): The operative cohort comprised 495 women undergoing laparoscopy/laparotomy between 2007 and 2009, and the population cohort comprised 131 women from the surgical centers' catchment areas. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Incidence of endometriosis by diagnostic method in the operative cohort and by pelvic magnetic resonance imaged (MRI) disease in the population cohort. RESULT(S): Endometriosis incidence in the operative cohort ranged by two orders of magnitude by diagnostic

Method

0.7% for only histology, 7% for only MRI, and 41% for visualized disease. Endometriosis staging was skewed toward minimal (58%) and mild disease (15%). The incidence of MRI-diagnosed endometriosis was 11% in the population cohort. CONCLUSION(S): Endometriosis incidence is dependent on the diagnostic method and choice of sampling framework. Conservatively, 11% of women have undiagnosed endometriosis at the population level, with implications for the design and interpretation of etiologic research.

Topics

EndometriosisDiagnostics
endometriosis incidence study population, ENDO study diagnostic method, endometriosis prevalence operative population, laparoscopic vs MRI endometriosis diagnosis, endometriosis epidemiology cohort, surgical confirmation endometriosis, population-based endometriosis prevalence, endometriosis detection methods comparison, endometriosis disease burden, undiagnosed endometriosis prevalence
PMID 21719000 21719000 DOI 10.1016/j.fertnstert.2011.05.087 10.1016/j.fertnstert.2011.05.087

Cite this article

Buck Louis, G. M., Hediger, M. L., Peterson, C. M., Croughan, M., Sundaram, R., Stanford, J., Chen, Z., Fujimoto, V. Y., Varner, M. W., Trumble, A., Giudice, L. C., & ENDO Study Working Group (2011). Incidence of endometriosis by study population and diagnostic method: the ENDO study. *Fertility and sterility*, *96*(2), 360-365. https://doi.org/10.1016/j.fertnstert.2011.05.087

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