0 Ask Beta Account

Disparities in Cardiovascular Disease Risk Among Hispanic Breast Cancer Survivors in a Population-Based Cohort

Chun-Pin E. Chang, David K. Gaffney, Chun-Pin Chang, Vikrant Deshmukh, Alison Fraser, Lisa H Gren, Mia Hashibe, N Lynn Henry, Qingqing Hu, Ivette Lopez, Michael Newman, Christina A Porucznik, Kerry Rowe, Ken R Smith, John Snyder, Joseph B Stanford

Open Access
  • University of Utah ROR
  • Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, United States of America.
  • Huntsman Cancer Institute ROR
  • University of Michigan ROR
  • Utah Valley University ROR
  • Intermountain Healthcare ROR

JNCI Cancer Spectrum, 5(2)

DOI 10.1093/jncics/pkab016 PMID 33889806

Abstract

Background

Breast cancer is the leading cause of cancer death among Hispanic women. The aim of our study was to estimate cardiovascular disease (CVD) risk among Hispanic and non-Hispanic White (NHW) breast cancer survivors compared with their respective general population cohorts.

Methods

Cohorts of 17 469 breast cancer survivors (1774 Hispanic and 15 695 NHW) in the Utah Cancer Registry diagnosed between 1997 and 2016, and 65 866 women (6209 Hispanic and 59 657 NHW) from the general population in the Utah Population Database were identified. Cox proportional hazards models were used to estimate hazard ratios (HRs) for CVD.

Results

The risk of diseases of the circulatory system was higher in Hispanic than NHW breast cancer survivors 1-5 years after cancer diagnosis, in comparison with their respective general population cohorts (HR(Hispanic) = 1.94, 99% confidence interval [CI] = 1.49 to 2.53; H(NHW) = 1.38, 99% CI = 1.33 to 1.43; 2-sided P (heterogeneity) = .01, respectively). Increased risks were observed for both Hispanic and NHW breast cancer survivors for diseases of the heart and the veins and lymphatics, compared with the general population cohorts. More than 5 years after cancer diagnosis, elevated risk of diseases of the veins and lymphatics persisted in both ethnicities. The CVD risk due to chemotherapy and hormone therapy was higher in Hispanic than NHW breast cancer survivors but did not differ for distant stage, higher baseline comorbidities, or baseline smoking.

Conclusions

We observed a risk difference for diseases of the circulatory system between Hispanic and NHW breast cancer survivors compared with their respective general population cohorts but only within the first 5 years of cancer diagnosis.

Topics

General OB/GYN
cardiovascular disease Hispanic breast cancer, CVD risk breast cancer survivors, health disparities Hispanic women, cancer survivorship cardiovascular, breast cancer treatment cardiac effects, population-based cohort cancer CVD, ethnic disparities cancer outcomes, Hispanic women cardiovascular risk factors, cancer survivor long-term health, breast cancer cardiovascular comorbidity
PMID 33889806 33889806 DOI 10.1093/jncics/pkab016 10.1093/jncics/pkab016

Cite this article

Hu, Q., Chang, C. P., Rowe, K., Snyder, J., Deshmukh, V., Newman, M., Fraser, A., Smith, K., Gren, L. H., Porucznik, C., Stanford, J. B., Gaffney, D., Henry, N. L., Lopez, I., & Hashibe, M. (2021). Disparities in Cardiovascular Disease Risk Among Hispanic Breast Cancer Survivors in a Population-Based Cohort. *JNCI cancer spectrum*, *5*(2). https://doi.org/10.1093/jncics/pkab016

Keywords

Antineoplastic Agents

Related articles