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Clonidine in the treatment of premenstrual syndrome: a subgroup study

Sullivan B

The Journal of Clinical Psychiatry, 49(2), 62-63

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Abstract

The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels. All of the women received clonidine and placebo in a double-blind cross-over design that spanned four menstrual cycles. Clonidine was significantly (p less than .05) more effective than placebo in reducing symptoms.

Topics

Reproductive Endocrinology > Premenstrual Syndrome > Pharmacological TreatmentMenstrual Cycle > Premenstrual Symptoms > Neuroendocrine MechanismsResearch Methodology > Clinical Trials > Double-Blind Crossover Design
clonidine premenstrual syndrome treatment double-blind crossover, PMS beta-endorphin deficiency clonidine therapy, premenstrual syndrome opioid endorphin pharmacological treatment, clonidine versus placebo premenstrual symptoms randomized trial, Giannini clonidine premenstrual syndrome endorphin, cyclic beta-endorphin decrease PMS subgroup treatment, alpha-adrenergic agonist premenstrual syndrome management, premenstrual syndrome neuroendocrine treatment clonidine, PMS moderate severe symptoms endorphin-based therapy, premenstrual dysphoric disorder pharmacological intervention crossover design

Cite this article

Giannini, A. J., Sullivan, B., Sarachene, J., & Loiselle, R. H. (1988). Clonidine in the treatment of premenstrual syndrome: a subgroup study. *The Journal of clinical psychiatry*, *49*(2), 62-63.

Keywords

Adult, Clinical Trials As Topic, Clonidine/therapeutic Use, Double-Blind Method, Female, Humans, Placebos, Premenstrual Syndrome/blood/drug Therapy/psychology, Psychiatric Status Rating Scales, beta-Endorphin/blood, Placebos, beta-Endorphin, Clonidine

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