Obstetrics and Gynecology, 59(3), 275-279
Sixty-nine infertile women with a midluteal serum progesterone level of 4 to 14 ng/ml were treated with a graduated dosage schedule of clomiphene citrate until the progesterone level on day 21 was greater than 20 ng/ml. Thirty-one pregnancies occurred, 58% during the first adequate treatment cycle and 19% during the second cycle. The abortion rate was 23%. After 6 adequate treatment cycles, laparoscopic evaluation was performed on 28 of 39 patients who did not conceive. Pathology was noted in 57%. Seven of 17 patients with intraperitoneal causes of infertility conceived after alternative therapy. The corrected pregnancy rate was 60%. Results of this study suggest that low luteal phase progesterone levels may compromise fertility and that clomiphene citrate enhances pregnancy rates.
Hammond, M. G., & Talbert, L. M. (1982). Clomiphene citrate therapy of infertile women with low luteal phase progesterone levels. *Obstetrics and gynecology*, *59*(3), 275-279.
Hammond MG, Talbert LM. Clomiphene citrate therapy of infertile women with low luteal phase progesterone levels. Obstet Gynecol. 1982;59(3):275-279.
Hammond, M. G., and L. M. Talbert. "Clomiphene citrate therapy of infertile women with low luteal phase progesterone levels." *Obstetrics and gynecology*, vol. 59, no. 3, 1982, pp. 275-279.
Adult, Clomiphene/analogs & Derivatives/therapeutic Use, Estradiol Congeners/therapeutic Use, Female, Humans, Infertility, Female/blood/drug Therapy, Luteal Phase/drug Effects, Menstruation/drug Effects, Pregnancy, Progesterone/blood, Estradiol Congeners, Clomiphene, Progesterone