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Clinical applications of LHRH and its analogues

Sandow J, 1983

Clinical endocrinology, 18(6), 571-592

DOI 10.1111/j.1365-2265.1983.tb00595.x PMID 6136347 Source

Abstract

The physiological requirement for activation of pituitary gonadotrophin secretion by pulsatile LHRH stimulation is discussed, and compared with the effect of pituitary stimulation by LHRH agonists. Initial stimulation is followed by a phase of progressive pituitary and gonadal inhibition. This inhibition is fully reversible at the end of agonist treatment. Clinical applications of high dose suppression are the treatment of precocious puberty and hormone-dependent tumours (mammary and prostatic carcinoma). In women, agonist administration by nasal spray is a reversible method of inhibiting ovulation, and may also be useful in the treatment of endometriosis. Clinical advantages of agonist therapy are favourable biological tolerance, lack of side effects and rapid reversibility.

Topics

Reproductive Endocrinology > Ovulation > PhysiologyContraception/Comparison > FABM vs Hormonal > Side EffectsEndometriosis > Medical Management > Hormonal
lhrh agonist ovulation suppression, gnrh analog clinical applications, buserelin endometriosis treatment, gonadotropin releasing hormone contraception, pituitary desensitization reversibility, lhrh nasal spray ovulation inhibition, gnrh agonist side effects fertility, precocious puberty lhrh treatment, hormone dependent tumor therapy, reversible contraceptive methods hormonal

Cite this article

Sandow, J. (1983). Clinical applications of LHRH and its analogues. *Clinical endocrinology*, *18*(6), 571-592. https://doi.org/10.1111/j.1365-2265.1983.tb00595.x

Keywords

Adolescent, Adult, Animals, Buserelin, Climacteric, Contraception, Corpus Luteum, Cryptorchidism, Female, Gonadotropin-Releasing Hormone, Humans, Hypogonadism, Luteinizing Hormone, Male, Ovulation, Pituitary Gland, Prostatic Neoplasms, Puberty, Delayed, Precocious, Rats, Testis, Age Factors, Amenorrhea, Laboratory, Biology, Breast Cancer, Cancer, Central Nervous System, Child, Contraception Research, Contraceptive Mode Of Action, Demographic Factors, Diseases, Endocrine System, Endometrial Effects, Endometrium, Family Planning, Follicle Stimulating Hormone, Genitalia, Gonadotropins, Hormones, Hypothalamus, Literature Review, Male Contraception, Menopause, Menstruation Disorders, Neoplasms, Ovary, Ovulation Suppression, Physiology, Pituitary Hormone Releasing Hormones--administraction and Dosage, Pituitary Hormone Releasing Hormones--therapeutic Use, Population, Population Characteristics, Prostate, Reproduction, Urogenital System, Uterus, Youth

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