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Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis

Almasi-Hashiani A et al., 2019

Almasi-Hashiani A, Omani-Samani R, Mohammadi M, Amini P, Navid B, Alizadeh A, Khedmati Morasae E, Maroufizadeh S

BMC pregnancy and childbirth, 19(1), 149, 2019

Source DOI PubMed

Abstract

Background

The objective of this systematic review and meta-analyses was to assess the risk of preeclampsia among women who conceived with assisted reproductive technology (ART).

Methods

We searched the ISI Web of Knowledge, Medline/PubMed, Scopus, and Embase (from inception to May 2017) for English language articles using a list of key words. In addition, reference lists from identified studies and relevant review articles were also searched. Data extraction was performed by two authors, and the study quality was assessed using the Newcastle-Ottawa Scale. Random-effects model meta-analysis was applied to pool the relative risks (RR) across studies.

Results

A total of 48 studies (5 case-control studies and 43 cohort studies) were included in this meta-analysis. The Cochran Q test and I(2) statistics revealed substantial heterogeneity (Q = 26,313.92, d.f. = 47, p < 0.001 and I(2) = 99.8%). Meta-analysis showed a significant increase in preeclampsia in women who conceived by ART compared with those who conceived spontaneously (RR = 1.71, 95% CI = 1.11-2.62, p = 0.015).

Conclusions

The findings of this systematic review indicate that the use of ART treatment is associated with a 1.71-fold increase in preeclampsia.

Topics

Pregnancy > Outcomes > ComplicationsContraception/Comparison > FABM vs Hormonal > EffectivenessInfertility > Couple-Based > Outcomes
ivf preeclampsia risk, assisted reproductive technology complications, art pregnancy outcomes, preeclampsia ivf meta-analysis, infertility treatment pregnancy risks, art versus natural conception outcomes, ivf maternal health risks, preeclampsia risk factors assisted reproduction, spontaneous conception versus art, fertility treatment pregnancy complications

Cite this article

Almasi-Hashiani, A., Omani-Samani, R., Mohammadi, M., Amini, P., Navid, B., Alizadeh, A., Khedmati Morasae, E., & Maroufizadeh, S. (2019). Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis. *BMC pregnancy and childbirth*, *19*(1), 149. https://doi.org/10.1186/s12884-019-2291-x

Keywords

Case-Control Studies, Cohort Studies, Female, Humans, Pre-Eclampsia, Pregnancy, Reproductive Techniques, Assisted, Risk, Assisted Reproductive Technology, Infertility, Meta-analysis, Preeclampsia, Systematic Review

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