International Journal of Environmental Research and Public Health, 15(6), E1079, 2018
Women's Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)
Osteoporosis Program, University Health Network, Toronto, ON M5G 2C4, Canada. marshapinto@gmail.com.
Department of Medicine and Joint Department of Medical Imaging, Centre of Excellence in Skeletal Health Assessment, University Health NetworkUniversity of TorontoTorontoONCanadaROR
Women's hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43⁻63 in the Canadian Multicentre Osteoporosis Study (CaMos), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12.2%. Women with VMSn were slightly younger (54.5 vs. 55.3 years, p = 0.02) and less likely to use sex steroid therapies (39.8% vs. 51.4%, p < 0.05). BMD at the lumbar spine (L1-4), femoral neck (FN) and total hip (TH) were similar between those with/without VMSn. In adjusted models, we did not find a significant association between VMSn and 2-year change in L1-4, FN and TH BMD. Age, reproductive status, weight, sex steroid therapy and smoking status were associated with 2-year change in BMD. Incident fractures over 2 years also did not differ by VMSn. Our analyses were restricted to VMSn and may not truly capture the relationship between VMS and BMD. Additional research involving VMS, bone loss and fracture incidence is needed.
Wong Tomlinson Prior night sweats bone mineral density 2-year change mid-life women, vasomotor symptoms perimenopause bone loss prospective population-based Canadian study, hot flushes night sweats 79% late perimenopause BMD loss association, VMS severity frequency spinal femoral bone density DXA longitudinal study, CaMos Canadian Multicentre Osteoporosis Study vasomotor bone mineral density, mid-life night sweats 2-year lumbar spine bone loss prospective observational, estrogen fluctuation vasomotor symptoms bone resorption perimenopause mechanism, night sweat intensity bone loss prediction mid-life women hormonal transition, International Journal Environmental Research Public Health 2018 VMS bone study, perimenopause vasomotor symptoms bone density change population-based evidence
PMID 29861446 29861446 DOI 10.3390/ijerph15061079 10.3390/ijerph15061079
Cite this article
Wong, E. M. M., Tomlinson, G., Pinto, M. M., Berger, C., Cheung, A. M., & Prior, J. C. (2018). Women's Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos). International journal of environmental research and public health, 15(6), E1079. https://doi.org/10.3390/ijerph15061079
Wong EMM, Tomlinson G, Pinto MM, Berger C, Cheung AM, Prior JC. Women's Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos). Int J Environ Res Public Health. 2018;15(6):E1079. doi:10.3390/ijerph15061079
Wong, E. M. M., et al. "Women's Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)." International journal of environmental research and public health, vol. 15, no. 6, 2018, pp. E1079.
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Zańko A et al., 2022·International journal of environmental research and public health
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Coccia ME et al., 2022·Int J Environ Res Public Health
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