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Variations in body mass index of users of depot-medroxyprogesterone acetate as a contraceptive

Pantoja M et al., 2010

Contraception, 81(2), 107-111

DOI 10.1016/j.contraception.2009.07.008 PMID 20103446 Source

Abstract

Background

Weight gain is a frequent reason for discontinuing the contraceptive with depot-medroxyprogesterone acetate (DMPA).

Study design

This 3-year retrospective cohort study assessed body mass index (BMI; kg/m(2)) variations in 379 current or past DMPA users compared to TCu380A intrauterine device (IUD) users matched for age and BMI, categorized into G1 (normal weight), G2 (overweight) or G3 (obese) according to baseline BMI. Variations in weight and BMI were evaluated using analysis of variance.

Results

BMI increased progressively in all groups but significantly more in G1 and G2 DMPA users compared to nonusers and according to duration of use. In the G3 subgroup, weight trends were similar in the DMPA and IUD users.

Conclusions

Normal and overweight women increased BMI with DMPA use; however, obese women did not increase weight. Weight increase in DMPA users could be associated with metabolic alterations related to duration of use in normal and overweight women and to alterations already present in obese women. Prospective studies are required to determine triggering factors. DMPA use <or=3 years was not associated with weight increase in women with BMI (kg/m(2)) >or=30.

Topics

Contraception/Comparison > Side Effects > Hormonal ContraceptionReproductive Endocrinology > Progesterone > Clinical Effects
depo provera weight gain body mass index, dmpa contraceptive weight changes over time, depot medroxyprogesterone acetate obesity, birth control shot weight gain by bmi, contraceptive injection weight increase normal weight, dmpa metabolic effects overweight women, depo shot versus iud weight comparison, progesterone injection weight trends obese women, injectable contraception body weight changes, medroxyprogesterone acetate discontinuation weight gain

Cite this article

Pantoja, M., Medeiros, T., Baccarin, M. C., Morais, S. S., Bahamondes, L., & Fernandes, A. M. (2010). Variations in body mass index of users of depot-medroxyprogesterone acetate as a contraceptive. *Contraception*, *81*(2), 107-111. https://doi.org/10.1016/j.contraception.2009.07.008

Keywords

Adult, Analysis of Variance, Body Mass Index, Body Weight, Cohort Studies, Contraceptive Agents, Female, Humans, Intrauterine Devices, Copper, Medroxyprogesterone Acetate, Obesity, Overweight, Retrospective Studies, Weight Gain

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