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Urogenital tract abnormalities in sons of women treated with diethylstilbestrol

Henderson BE et al., 1976

Pediatrics, 58(4), 505-507

PMID 972792 Source

Abstract

Since in utero exposure to diethylstilbestrol (DES) is known to cause abnormalities of the female genital tract later in life, exposed male offspring were located, surveyed by mail, and compared with unexposed male offspring from the same period and medical practices. The exposed and unexposed respondents appeared comparable and did not differ in their response to most medical questions. However, a larger proportion of exposed than of unexposed boys had experienced problems in passing urine (12.9% vs. 1.8%, P = .0003) and abnormalities of the penile urethra (4.4% vs. 0%; P = .017).

Topics

General OB/GYN > Other > MiscellaneousEthics/Philosophy > Bioethics > Reproductive Technology
diethylstilbestrol male offspring abnormalities, DES exposed sons urogenital defects, prenatal DES exposure male reproductive tract, hypospadias DES exposure, urethral stricture DES sons, synthetic estrogen pregnancy complications, in utero hormonal exposure male genitalia, DES urinary problems boys, penile urethra abnormalities DES

Cite this article

Henderson, B. E., Benton, B., Cosgrove, M. D., Baptista, J., Aldrich, J. O., Townsend, D. E., Hart, W. R., & Mack, T. M. (1976). Urogenital tract abnormalities in sons of women treated with diethylstilbestrol. *Pediatrics*, *58*(4), 505-507.

Keywords

Abnormalities, Drug-Induced, Diethylstilbestrol, Female, Fetus, Humans, Hypospadias, Male, Pregnancy, Pregnancy Complications, Sex Factors, Urethral Stricture, Urogenital Abnormalities

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