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The value of luteal support with progesterone in gonadotropin-induced cycles

Hamilton CJ et al., 1993

Fertility and sterility, 60(5), 786-790

DOI 10.1016/s0015-0282(16)56277-3 PMID 8224262 Source

Abstract

Objective

To evaluate the effect of luteal support with vaginal P suppositories in hMG- and hCG-induced cycles.

Design

Between March 1988 and February 1989 patients did not receive luteal support, while between March 1989 and January 1990 P was given routinely in the luteal phase. Induction protocol and patient selection remained otherwise unchanged.

Setting

Infertility clinic of a tertiary care hospital.

Patients

Twenty-seven patients with hypogonadotropic amenorrhea (World Health Organization [WHO] group I) (11 women with luteal support, 16 women without) and 102 patients with euprolactinemic clomiphene citrate (CC)-resistant anovulation (WHO group II) (52 women with luteal support, 50 women without).

Intervention

Vaginal P suppositories 200 mg/d in the luteal support group.

Main outcome measures

Pregnancy rate (PR), pregnancy outcome.

Results

The overall PR in 118 cycles with luteal support was 26.3% whereas 10.4% pregnancies were achieved in 115 cycles of the control group. The influence of luteal support was more pronounced in patients with CC-resistant anovulation (25.2% versus 6.9%) than in patients with hypogonadotropic amenorrhea (33.3% versus 21.4%, not significant). The abortion rate was not significantly changed.

Conclusion

Luteal support with P increases the PR after hMG and hCG induction. The need for supplementary P seems to be related to the underlying cause of ovarian disturbance.

Topics

Reproductive Endocrinology > Luteal Phase > SupportInfertility > Female Factor > Ovulatory DysfunctionReproductive Endocrinology > Progesterone > Supplementation
luteal phase support gonadotropin cycles, progesterone supplementation ovulation induction, vaginal progesterone suppositories fertility, menotropin cycle luteal support, hcg trigger progesterone support, luteal phase deficiency gonadotropins, progesterone pregnancy outcomes fertility treatment, corpus luteum support clomid cycles, assisted conception luteal progesterone

Cite this article

Hamilton, C. J., Jaroudi, K. A., & Sieck, U. V. (1993). The value of luteal support with progesterone in gonadotropin-induced cycles. *Fertility and sterility*, *60*(5), 786-790. https://doi.org/10.1016/s0015-0282(16)56277-3

Keywords

Abortion, Spontaneous, Adult, Chorionic Gonadotropin, Corpus Luteum, Estradiol, Female, Humans, Menotropins, Ovulation Induction, Pessaries, Pregnancy, Pregnancy Outcome, Progesterone, Retrospective Studies

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