We have retrospectively studied the changes in the level of C-reactive protein (CRP) and of white blood cells in 82 patients who had premature rupture of the membranes between the 20th and the 36th week of pregnancy in order to estimate the possibility of prenatal screening for amnion infections in early rupture of the membranes. The level of CRP was shown to be quickly and significantly raised in cases of clinical or histological chorioamnionitis, whereas the change in maternal leucocytes alters little and later. The level of CRP can be worked out as an early biological marker which is sensitive and cheap in the clinical supervision of cases with early rupture of the membranes.
Chaaban, M., Jauniaux, E., Nasreddine, S., Jabry, S., Duchateau, J., & Wilkin, P. (1988). The significance of C-reactive protein in the diagnosis of chorioamnionitis in cases of premature rupture of the membranes. *Journal de gynecologie, obstetrique et biologie de la reproduction*, *17*(8), 1045-1049.
Chaaban M, Jauniaux E, Nasreddine S, Jabry S, Duchateau J, Wilkin P. The significance of C-reactive protein in the diagnosis of chorioamnionitis in cases of premature rupture of the membranes. J Gynecol Obstet Biol Reprod (Paris). 1988;17(8):1045-1049.
Chaaban, Mohamad, et al. "The significance of C-reactive protein in the diagnosis of chorioamnionitis in cases of premature rupture of the membranes." *Journal de gynecologie, obstetrique et biologie de la reproduction*, vol. 17, no. 8, 1988, pp. 1045-1049.
OBJECTIVE: To determine whether adrenomedullin levels in amniotic fluid were associated with preterm labor.
METHODS: We measured immunoreactive adrenomedullin in amniotic fluid collected by amniocent...
The purpose of our study was to analyze the efficacy of serum C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) serial evaluations in the prediction of ch...
Pregnancy > Complications > Premature Rupture of MembranesDiagnostics > Biomarkers > C-Reactive Protein in PregnancyPregnancy > Infections > Chorioamnionitis Detection
OBJECTIVE: To determine whether serum interleukin-6 concentrations predict impending preterm delivery.
METHODS: Blood samples were collected from 130 gravidas at 22-34 weeks' gestation. The study gro...
Stiemer B et al., 1997British Journal of Obstetrics and Gynaecology
Interleukin-8 (IL-8), a 72 amino acid peptide secreted by cells of the immune system and of the amnion, chorion and decidua, was measured in women in late pregnancy. IL-8 was detected in the urine of ...