The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium
Paediatric and perinatal epidemiology, 33(6), 490-502, 2019
Abstract
Background
Preconception health may have intergenerational influences. We have formed the PrePARED (Preconception Period Analysis of Risks and Exposures influencing health and Development) research consortium to address methodological, conceptual, and generalisability gaps in the literature.
Objectives
The consortium will investigate the effects of preconception exposures on four sets of
Outcomes
(1) fertility and miscarriage; (2) pregnancy-related conditions; (3) perinatal and child health; and (4) adult health outcomes. POPULATION: A study is eligible if it has data measured for at least one preconception time point, has a minimum of selected core data, and is open to collaboration and data harmonisation.
Design
The included studies are a mix of studies following women or couples intending to conceive, general-health cohorts that cover the reproductive years, and pregnancy/child cohort studies that have been linked with preconception data. The majority of the participating studies are prospective cohorts, but a few are clinical trials or record linkages.
Methods
Data analysis will begin with harmonisation of data collected across cohorts. Initial areas of interest include nutrition and obesity; tobacco, marijuana, and other substance use; and cardiovascular risk factors. PRELIMINARY
Results
Twenty-three cohorts with data on almost 200 000 women have combined to form this consortium, begun in 2018. Twelve studies are of women or couples actively planning pregnancy, and six are general-population cohorts that cover the reproductive years; the remainder have some other design. The primary focus for four was cardiovascular health, eight was fertility, one was environmental exposures, three was child health, and the remainder general women's health. Among other cohorts assessed for inclusion, the most common reason for ineligibility was lack of prospectively collected preconception data.
Conclusions
The consortium will serve as a resource for research in many subject areas related to preconception health, with implications for science, practice, and policy.
Topics
Cite this article
Harville, E. W., Mishra, G. D., Yeung, E., Mumford, S. L., Schisterman, E. F., Jukic, A. M., Hatch, E. E., Mikkelsen, E. M., Jiang, H., Ehrenthal, D. B., Porucznik, C. A., Wen, S. W., Harvey, A., Symons Downs, D., Yajnik, C., Santillan, D., Santillan, M., McElrath, T. F., Woo, J. G., . . . Stanford, J. B. (2019). The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium. *Paediatric and perinatal epidemiology*, *33*(6), 490-502. https://doi.org/10.1111/ppe.12592
Harville EW, Mishra GD, Yeung E, Mumford SL, Schisterman EF, Jukic AM, et al. The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium. Paediatr Perinat Epidemiol. 2019;33(6):490-502. doi:10.1111/ppe.12592
Harville, E. W., et al. "The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium." *Paediatric and perinatal epidemiology*, vol. 33, no. 6, 2019, pp. 490-502.
Keywords
Adult, Biomedical Research, Child Health, Female, Humans, Infant Health, Infertility, Intersectoral Collaboration, Male, Maternal Exposure, Paternal Exposure, Preconception Care, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Research Design, Research Support As Topic, Birthweight, Cohort Studies, Common Data Elements, Fertility