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The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis

Oosterlynck DJ et al., 1992

Oosterlynck DJ, Meuleman C, Waer M, Vandeputte M, Koninckx PR

Fertility and sterility, 58(2), 290-295, 1992

Source DOI PubMed

Abstract

Objective

To investigate the local natural killer (NK) activity of the peritoneal fluid mononuclear cells (PFMC). DESIGN

Patients

In a prospective way, the NK activity (K562-assay) was measured in peripheral blood (PB) and peritoneal fluid (PF) of 44 women who underwent a laparoscopy for infertility and/or pain at the University Hospital of Gasthuisberg, Leuven, Belgium.

Main outcome measure

The NK activity of peripheral blood mononuclear cells and PFMC, the number and concentration of PFMC, the percentage of lymphocytes versus macrophages by May-Grünwald-Giemsa staining and the estradiol and progesterone concentration of the PF were correlated together and with the severity of endometriosis.

Results

We demonstrated that there is a significant NK activity in PF and that this activity is decreased in women with endometriosis. This defect was more pronounced in the follicular phase of the cycle compared with the postovulatory phase. In PB of the same 44 women, the decreased NK activity correlated with the severity of the disease. This confirms our previous report on another 34 women.

Conclusions

The NK activity is decreased in women with endometriosis and correlated significantly with the severity of the disease in both the PB and PF of women with endometriosis.

Topics

Endometriosis > Pathophysiology > MechanismsEndometriosis > Pathophysiology > BiomarkersInfertility > Female Factor > Endometriosis-Related
natural killer cells endometriosis, peritoneal fluid immune dysfunction endometriosis, nk cell activity endometriosis infertility, endometriosis immune system pathophysiology, peritoneal lymphocytes endometriosis, natural killer deficiency endometriosis severity, endometriosis immunology mechanisms, peritoneal fluid nk activity follicular luteal phase, endometriosis stage immune function correlation, endometriosis-associated infertility immune factors

Cite this article

Oosterlynck, D. J., Meuleman, C., Waer, M., Vandeputte, M., & Koninckx, P. R. (1992). The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. *Fertility and sterility*, *58*(2), 290-295. https://doi.org/10.1016/s0015-0282(16)55224-8

Keywords

Ascitic Fluid, Endometriosis, Female, Humans, Killer Cells, Natural, Leukocytes, Mononuclear, Menstrual Cycle, Prospective Studies

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