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The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone

Rosenberg SM et al., 1980

Fertility and sterility, 34(1), 17-20

DOI 10.1016/s0015-0282(16)44831-4 PMID 7398902 Source

Abstract

Three hundred and ninety-six patients were evaluated for primary and secondary infertility between December 1976 and May 1979 at a large referral center. Timed late luteal endometrial biopsies were routinely obtained as part of the work-up and were repeated for confirmation if subsequent menses did not occur within 2 days of the expected date. If both biopsies were abnormal, a diagnosis of luteal phase defect (LPD) was made and patients were treated with vaginal progesterone suppositories for a minimum of 6 months. LPD was discovered in 32 of 396 patients (8.1%); among those patients whose infertility was not complicated by other abnormalities, 9 of 13 conceived (70%) and 7 of 13 carried to term (54%). These data suggest an incidence higher than generally recognized and a very encouraging response to replacement therapy.

Topics

RRM Methods > NaProTECHNOLOGY > Clinical OutcomesReproductive Endocrinology > Luteal Phase > DeficiencyReproductive Endocrinology > Progesterone > SupplementationInfertility > Female Factor > Ovulatory Dysfunction
luteal phase defect diagnosis treatment, endometrial biopsy timing infertility, progesterone suppositories luteal support, vaginal progesterone luteal phase deficiency, lpd incidence infertility, progesterone replacement therapy conception, timed endometrial biopsy luteal phase, luteal phase insufficiency pregnancy outcomes, progesterone deficiency treatment infertility, endometrial dating luteal phase defect, vaginal progesterone infertility success, luteal phase support pregnancy rates

Cite this article

Rosenberg, S. M., Luciano, A. A., & Riddick, D. H. (1980). The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone. *Fertility and sterility*, *34*(1), 17-20. https://doi.org/10.1016/s0015-0282(16)44831-4

Keywords

Female, Humans, Infertility, Luteal Phase, Pregnancy, Progesterone, Suppositories, Vagina, Americas, Biology, Connecticut, Developed Countries, Endocrine System, Hormones, North America, Northern America, Physiology, Progestational Hormones, Reproduction, United States

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