The gamete and embryo compatibility of various synthetic polymers

Hunter SK, Scott JR, Hull D, Urry RL

doi:10.1016/s0015-0282(16)60017-1

The gamete and embryo compatibility of various synthetic polymers

S K Hunter, J R Scott, Dale B. Hull, R L Urry

University of Utah ROR

Fertility and Sterility, 50(1), 110-116

DOI 10.1016/s0015-0282(16)60017-1 PMID 3384103

Abstract

Several popular and well-characterized polymeric materials were evaluated for their biocompatibility toward the cells unique to reproduction. To accomplish these studies, several in vitro tests were developed that evaluated biocompatibility between the polymers and spermatozoa, ova, and embryos. The data indicated significant differences between the materials with respect to their biocompatibility toward sperm motility, the sperm's ability to penetrate zona-free hamster eggs, and the ability of two-cell mouse embryos to divide. Polytetrafluoroethylene (PTFE-Teflon; PTFE, Chemplast Inc., Wayne, NJ), polyethylene glycol (PEG), and polyhydroxyethyl methacrylate (PHEMA) appear to be the most inert of the materials studied. Polyvinyl chloride (PVC; Tygon-Norton, Akron, OH) was found to be the most detrimental material toward gametes and embryos, with gross physiologic and morphologic changes observed in the PVC-exposed cells.

Topics

Research Methodology > In Vitro Testing > Biomaterial Compatibility Infertility > Laboratory Methods > Gamete Handling Materials

synthetic polymer biocompatibility gametes embryos, polyvinyl chloride sperm motility toxicity, PTFE Teflon biocompatibility reproductive cells, polymer biocompatibility zona free hamster egg penetration, two cell mouse embryo division polymer exposure, polyethylene glycol PHEMA gamete compatibility, in vitro sperm motility polymer testing, biomaterial toxicity spermatozoa ova embryos, PVC Tygon reproductive cell damage, synthetic materials reproductive medicine laboratory

PMID 3384103 3384103 DOI 10.1016/s0015-0282(16)60017-1 10.1016/s0015-0282(16)60017-1

Cite this article

Hunter, S. K., Scott, J. R., Hull, D. B., & Urry, R. L. (1988). The gamete and embryo compatibility of various synthetic polymers. *Fertility and sterility*, *50*(1), 110-116. https://doi.org/10.1016/s0015-0282(16)60017-1

Keywords

Animals, Biocompatible Materials, Cricetinae, Dimethylpolysiloxanes/pharmacology, Embryo Transfer, Embryo, Mammalian/drug Effects, Female, Fertilization in Vitro, Humans, Male, Mice, Polyethylenes/pharmacology, Polymers/pharmacology, Polytetrafluoroethylene/pharmacology, Polyurethanes/pharmacology, Polyvinyl Chloride/pharmacology, Sperm-Ovum Interactions/drug Effects, Spermatozoa/drug Effects, Biocompatible Materials, Dimethylpolysiloxanes, Polyethylenes, Polymers, Polyurethanes, Polytetrafluoroethylene, Polyvinyl Chloride

The gamete and embryo compatibility of various synthetic polymers

Abstract

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Cite this article

Keywords

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