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The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism

Bayram F et al., 1996

Fertility and sterility, 66(2), 220-222

DOI 10.1016/s0015-0282(16)58442-8 PMID 8690105 Source

Abstract

Objective

To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism.

Design

Nonrandomized, prospective clinical trial.

Patients

Forty-one patients with moderate-severe hirsutism were included in the study.

Intervention

Hirsute patients received 250 mg/d flutamide for a period of 6 months.

Main outcome measures

Hirsutism score, FSH, LH, E2, total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment.

Results

Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48 +/- 5.35 to 5.07 +/- 2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study.

Conclusion

The low-dose flutamide, 250 mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750 mg/d.

Topics

PCOS > Treatment > PharmacologicalPCOS > Pathophysiology > Hyperandrogenism
flutamide treatment for hirsutism, low dose antiandrogen hirsutism outcomes, flutamide 250 mg hirsutism score, androgen blocker for excess hair growth, hirsutism treatment pharmacological, pcos hirsutism management with flutamide, hyperandrogenism treatment options, antiandrogen therapy unwanted facial hair, cost-effective hirsutism medication

Cite this article

Bayram, F., Sahin, Y., Keleştimur, F., Tutuş, A., Ayata, D., & Müderris, I. I. (1996). The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. *Fertility and sterility*, *66*(2), 220-222. https://doi.org/10.1016/s0015-0282(16)58442-8

Keywords

Adolescent, Adult, Androgen Antagonists, Androstenedione, Dose-Response Relationship, Drug, Estrogens, Female, Flutamide, Follicle Stimulating Hormone, Hirsutism, Humans, Luteinizing Hormone, Progesterone, Prospective Studies, Testosterone

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