Journal of the American College of Nutrition, 2(2), 115-122
In a double-blind, randomized dose-response study, 75 women with benign breast disease were administered a written questionnaire in which they scored the severity of premenstrual syndrome (PMS) symptoms before and after two months of treatment with placebo or alpha-tocopherol (150, 300, or 600 IU/day). Controlling for age and pretreatment scores, alpha-tocopherol had a significantly greater effect than placebo, improving three of the four classes of PMS symptoms. These findings suggest that vitamin E supplementation may be of value in women with severe PMS symptoms.
London, R. S., Sundaram, G. S., Murphy, L., & Goldstein, P. J. (1983). The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. *Journal of the American College of Nutrition*, *2*(2), 115-122. https://doi.org/10.1080/07315724.1983.10719916
London RS, Sundaram GS, Murphy L, Goldstein PJ. The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. J Am Coll Nutr. 1983;2(2):115-122. doi:10.1080/07315724.1983.10719916
London, R. S., et al. "The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study." *Journal of the American College of Nutrition*, vol. 2, no. 2, 1983, pp. 115-122.
Adolescent, Adult, Clinical Trials As Topic, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Menstruation Disturbances/drug Therapy, Middle Aged, Premenstrual Syndrome/drug Therapy, Syndrome, Vitamin E/therapeutic Use, Vitamin E