The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years
Contraception, 84(4), 357-362
Abstract
Background
The associations between oral contraceptive (OC) use, bone mineral density (BMD) and the risk of fractures remain controversial.
Study design
A cross-sectional study of 491 women aged 50-80 years was performed. We assessed OC use and fractures by questionnaire, and BMD and vertebral deformity by dual-energy x-ray absorptiometry.
Results
Ever use of OC was associated with significantly higher BMD at the total body (6%, p<.001) and spine (4%; p=.05) (but not hip) after adjustment for confounders. There was also a significant association between duration of OC use and total body and spine BMD. Use of OCs for 5-10 years was associated with reduced vertebral deformity (adjusted odds ratio 0.46, 95% confidence interval 0.22-0.94).
Conclusions
Oral contraceptive use and duration were associated with higher total body and spine BMD and a consistent reduction in vertebral deformities, although most associations did not reach significance.
Topics
Cite this article
Wei, S., Venn, A., Ding, C., Foley, S., Laslett, L., & Jones, G. (2011). The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years. *Contraception*, *84*(4), 357-362. https://doi.org/10.1016/j.contraception.2011.02.001
Wei S, Venn A, Ding C, Foley S, Laslett L, Jones G. The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years. Contraception. 2011;84(4):357-362. doi:10.1016/j.contraception.2011.02.001
Wei, Shuying, et al. "The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years." *Contraception*, vol. 84, no. 4, 2011, pp. 357-362.