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The association between endometriosis and chronic endometritis

Takebayashi A et al., 2014

PloS one, 9(2), e88354

DOI 10.1371/journal.pone.0088354 PMID 24558386 Source

Abstract

Objective

To evaluate the association between endometriosis and chronic endometritis.

Methods

Endometrial specimens were obtained from 71 patients, 34 with endometriosis (endometriosis group) and 37 without endometriosis (non-endometriosis group), who underwent hysterectomy, and the specimens were immunostained for the plasmacyte marker CD138. The rate of chronic endometritis was compared between the endometriosis group and the non-endometriosis group. Furthermore, the 71 patients were also divided into two groups, 28 with chronic endometritis (chronic endometritis group) and 43 without chronic endometritis (non-chronic endometritis group). Logistic regression analysis was performed with variables including age, body mass index (BMI), gravidity and parity, and diagnoses of leiomyoma, adenomyosis, and endometriosis on pathology to examine the independent effect of each variable on chronic endometritis. Patients suffering from cervical invasive carcinoma, endometrial carcinoma, and endometrial polyps or treated with gonadotropin-releasing hormone agonists, progestins, or oral contraceptives before surgery were excluded.

Results

Chronic endometritis was identified in 52.94% of the endometriosis group and 27.02% of the non-endometriosis group (p<0.05). Logistic regression analysis revealed that endometriosis was associated with chronic endometritis.

Conclusions

This result suggests a strong association between endometriosis and chronic endometritis.

Topics

Endometriosis > Pathophysiology > MechanismsDiagnostics > Biomarker Monitoring > Endometrial AssessmentInfertility > Female Factor > Endometriosis-Related
chronic endometritis and endometriosis, endometritis infertility connection, cd138 immunostaining endometrium, plasma cell endometritis diagnosis, chronic inflammation endometrium, endometrial infection and endometriosis, endometritis diagnostic workup, chronic endometritis treatment, uterine inflammation infertility, endometrial biomarkers endometriosis, plasmacyte marker endometrium

Cite this article

Takebayashi, A., Kimura, F., Kishi, Y., Ishida, M., Takahashi, A., Yamanaka, A., Takahashi, K., Suginami, H., & Murakami, T. (2014). The association between endometriosis and chronic endometritis. *PloS one*, *9*(2), e88354. https://doi.org/10.1371/journal.pone.0088354

Keywords

Adenomyosis, Adult, Body Mass Index, Endometriosis, Endometritis, Female, Humans, Hysterectomy, Leiomyoma, Logistic Models, Menstrual Cycle, Middle Aged, Regression Analysis, Syndecan-1, Uterus

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