The Journal of Clinical Endocrinology and Metabolism, 51(1), 173-175
The administration of small doses of LHRH at 2-hourly intervals over a 27 day period to a 24-year old patient with Kallman's syndrome resulted in ovulation as indicated by: (1) a biphasic temperature response, (2) anatomical changes in the ovaries demonstrated by ultrasound, and (3) the pattern of circulating gonadotropin and gonadal steroid concentrations.
Crowley, W. F., & McArthur, J. W. (1980). Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH). *The Journal of clinical endocrinology and metabolism*, *51*(1), 173-175. https://doi.org/10.1210/jcem-51-1-173
Crowley WF, McArthur JW. Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH). J Clin Endocrinol Metab. 1980;51(1):173-175. doi:10.1210/jcem-51-1-173
Crowley, William F., and Janet W. McArthur. "Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH)." *The Journal of clinical endocrinology and metabolism*, vol. 51, no. 1, 1980, pp. 173-175.
Adult, Amenorrhea/drug Therapy/pathology/physiopathology, Cervix Mucus/physiology, Estradiol/blood, Female, Gonadotropin-Releasing Hormone/administration & Dosage/therapeutic Use, Gonadotropins/blood, Humans, Menstruation-Inducing Agents/administration & Dosage, Ovary/anatomy & Histology, Ovulation Induction/methods, Progesterone/blood, Syndrome, Gonadotropins, Menstruation-Inducing Agents, Gonadotropin-Releasing Hormone, Progesterone, Estradiol