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Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

Harrison RF et al., 1978

British journal of obstetrics and gynaecology, 85(12), 927-932

DOI 10.1111/j.1471-0528.1978.tb15855.x PMID 737159 Source

Abstract

Plasma progesterone, 17-hydroxyprogesterone, 20alpha hydroxypregn-4-en-3-one levels were determined twice weekly up to 16 weeks gestation, where possible, in a twin pregnancy, in two patients who aborted spontaneously and in three patients who were treated with 'progesterone supplements' because of abnormal vaginal cytology. There was no correlation between vaginal smears and the plasms hormone levels and there was no evidence to suggest that progesterone supplements influenced clinical outcome. Compared with normal mean values the only difference was a significantly rise in progesterone and 20alpha hydroxypregn-4-en-3-one levels in the twin pregnancy after the 12th week and a precipitate fall in all hormone levels just prior to abortion. Plasma hormone levels could not be used to predict outcome.

Topics

Pregnancy > Recurrent Loss > TreatmentReproductive Endocrinology > Progesterone > SupplementationReproductive Endocrinology > Progesterone > AssaysPregnancy > Outcomes > Miscarriage Rates
progesterone levels early pregnancy loss, 17 hydroxyprogesterone spontaneous abortion, progesterone supplementation threatened miscarriage, plasma progesterone twin pregnancy, progesterone metabolites prediction abortion, hormone levels early pregnancy complications, vaginal cytology progesterone treatment, 20 alpha hydroxypregnenone miscarriage, first trimester progesterone support

Cite this article

Harrison, R. F., Youssefnejadian, E., Brodovcky, H., Johnson, M., & Dewhurst, J. (1978). Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy. *British journal of obstetrics and gynaecology*, *85*(12), 927-932. https://doi.org/10.1111/j.1471-0528.1978.tb15855.x

Keywords

20-alpha-Dihydroprogesterone, Abortion, Spontaneous, Female, Humans, Hydroxyprogesterones, Pregnancy, Pregnancy Complications, Pregnancy Trimester, First, Multiple, Progesterone, Progesterone Congeners

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