Results of in vivo and in vitro studies for assessing prenatal toxicity

Environmental health perspectives, 70, 89-103

DOI 10.1289/ehp.867089 PMID 3104025 Source

Abstract

Examples of a combined approach using in vivo as well as in vitro methods for the assessment of prenatal toxicity are presented. The topics discussed include the analysis of the possible embryotoxic potential of valproic acid (VPA), female sex hormones, bis(tri-n-butyltin) oxide (TBTO), and acyclovir and the problem of supplementing in vitro systems with drug-metabolizing activity.

Topics

prenatal toxicity assessment methods, valproic acid embryotoxicity, in vitro teratogenicity testing, sex hormone embryo toxicity, drug metabolizing embryo culture, acyclovir prenatal safety, in vivo in vitro teratogen screening, pharmaceutical embryotoxic potential

Cite this article

Neubert, D., Blankenburg, G., Chahoud, I., Franz, G., Herken, R., Kastner, M., Klug, S., Kröger, J., Krowke, R., & Lewandowski, C. (1986). Results of in vivo and in vitro studies for assessing prenatal toxicity. *Environmental health perspectives*, *70*, 89-103. https://doi.org/10.1289/ehp.867089

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