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Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer

Zhong YP et al., 2012

International journal of medical sciences, 9(2), 121-125

DOI 10.7150/ijms.3467 PMID 22253557 Source

Abstract

Objective

To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).

Methods

A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed.

Results

There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%).

Conclusion

Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.

Topics

Reproductive Endocrinology > Thyroid > AutoimmuneInfertility > Female Factor > UnexplainedPregnancy > Recurrent Loss > EtiologyDiagnostics > Hormone Assays > Thyroid
antithyroid antibodies IVF outcomes, thyroid autoimmunity infertility treatment, thyroid antibody pregnancy rates IVF, autoimmune thyroid disease embryo implantation, thyroid antibody testing fertility workup, ATA positive IVF miscarriage risk, thyroid autoantibodies fertilization rates, thyroid screening infertility evaluation, autoimmune thyroid IVF success rates, antithyroid antibody recurrent pregnancy loss

Cite this article

Zhong, Y. P., Ying, Y., Wu, H. T., Zhou, C. Q., Xu, Y. W., Wang, Q., Li, J., & Shen, X. T. (2012). Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer. *International journal of medical sciences*, *9*(2), 121-125. https://doi.org/10.7150/ijms.3467

Keywords

Adult, Autoantibodies, Autoimmune Diseases, Case-Control Studies, Embryo Transfer, Female, Fertilization in Vitro, Humans, Immunoglobulins, Thyroid-Stimulating, Infertility, Male, Middle Aged, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prognosis, Sperm Injections, Intracytoplasmic, Thyroid Diseases, Young Adult, In Vitro Fertilization and Embryo Transfer, Thyroid Auto-antibodies

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