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Progestin-primed ovarian stimulation protocol in patients undergoing assisted reproductive technology

Shanqin Qi, Yang Liu, Kehua Wang, Haiyan Yu, Yu Haiyan, Xiaojing Yang, Qinghan Shi, Liu Yang, J W Johnson

  • Shandong University of Traditional Chinese Medicine ROR
  • Shanxi Province Hospital of Traditional Chinese Medicine ROR
  • Affiliated Hospital of Shandong University of Traditional Chinese Medicine ROR
  • The First Clinical Medical College, Shandong University of Traditional Chinese Medicine
  • Qingdao University ROR
  • Department of Preventive Health Care of Traditional Chinese Medicine, Tai’an Hospital of Traditional Chinese Medicine

Frontiers in reproductive health, 7, 1719930

DOI 10.3389/frph.2025.1719930 PMID 41659361

Abstract

Purpose

To evaluate the effectiveness and safety of the novel protocol-progestin-primed ovarian stimulation (PPOS) protocol during controlled ovarian hyperstimulation (COH), in patients undergoing in vitro fertilization/intracytopalsmic sperm injection and embryo transfer (IVF/ICSI-ET).

Methods

By reviewing and analyzing published studies since PPOS protocol was firstly reported in 2015, we compared differences in ovarian stimulation characteristics, embryological features, pregnancy rates, and neonatal outcomes between PPOS protocol and conventional regimens employed in assisted reproductive technology (ART), and discussed the advantages and limitations of PPOS protocol.

MAIN

Finding

By adding exogenous progestin (P) during early follicular phase, PPOS scheme provide robust control over preovulatory luteinizing hormone (LH) surge and spontaneous ovulation, which promote oocyte maturation and recovery. Compared to various traditional protocols, PPOS achieved promising clinical pregnancy results, and equivalent rates of birth defect and congenital malformation. Moreover, it possessed significantly lower risk of ovarian hyperstimlation syndrome (OHSS).

Conclusion

Not inferior or comparable outcomes indicated that PPOS protocol is a competent alternative for ART with no obviously detrimental impact on oocyte development and embryo quality.

Topics

InfertilityReproductive Endocrinology
progestin-primed ovarian stimulation, PPOS protocol IVF outcomes, premature LH surge prevention, controlled ovarian hyperstimulation progestin, IVF ICSI ovarian stimulation protocol, medroxyprogesterone acetate ovarian stimulation, oocyte quality PPOS protocol, embryo competence progestin priming, novel ovarian stimulation protocol, reproductive outcome PPOS
PMID 41659361 41659361 DOI 10.3389/frph.2025.1719930 10.3389/frph.2025.1719930

Cite this article

Johnson, J. W. C., & Dubin, N. H. (1984). *Progestins in the Prevention of Preterm Birth*.

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