The Annals of Pharmacotherapy, 46(12), e36, 2012
To present a series of cases demonstrating successful reversal of mifepristone effects in women who chose to reverse the medical abortion process.
Four of 6 women who took mifepristone were able to carry their pregnancies to term after receiving intramuscular progesterone 200 mg.
Mifepristone has been available in the US since 2000. By 2008, approximately 25% of abortions prior to 9 weeks were accomplished with mifepristone. Some women who take mifepristone wish to reverse the medical abortion process. Progesterone competes with mifepristone for the progesterone receptor and may reverse the effects of mifepristone. A PubMed literature search from 1996 to May 2012 did not reveal any trials or case studies evaluating the efficacy of progesterone use to reverse the effects of mifepristone.
Health care professionals should be aware of the possible use of progesterone to reverse mifepristone in women who have begun the medical abortion process by taking mifepristone and then change their minds.
Delgado, G., & Davenport, M. L. (2012). Progesterone use to reverse the effects of mifepristone. *The Annals of pharmacotherapy*, *46*(12), e36. https://doi.org/10.1345/aph.1R252
Delgado G, Davenport ML. Progesterone use to reverse the effects of mifepristone. Ann Pharmacother. 2012;46(12):e36. doi:10.1345/aph.1R252
Delgado, George, and Mary L. Davenport. "Progesterone use to reverse the effects of mifepristone." *The Annals of pharmacotherapy*, vol. 46, no. 12, 2012, pp. e36.
Abortifacient Agents, Steroidal/administration & Dosage/antagonists & Inhibitors, Abortion, Induced/methods, Adult, Female, Humans, Injections, Intramuscular, Mifepristone/administration & Dosage/antagonists & Inhibitors, Pregnancy, Pregnancy Outcome, Progesterone/pharmacology, Receptors, Progesterone/drug Effects/metabolism, Young Adult, Abortifacient Agents, Steroidal, Receptors, Progesterone, Mifepristone, Progesterone