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Prior oral contraception and postmenopausal fracture: a Women's Health Initiative observational cohort study

Barad D et al., 2005

Barad D, Kooperberg C, Wactawski-Wende J, Liu J, Hendrix SL, Watts NB

Fertility and sterility, 84(2), 374-383, 2005

Source DOI PubMed

Abstract

Objective

To test for the possible association of past oral contraceptive (OC) use and incident fracture after menopause.

Design

A prospective cohort of 93,725 postmenopausal women.

Setting

Forty Women's Health Initiative (WHI) clinical centers across the United States. PATIENT(S): Ethnically diverse 93,725 volunteer postmenopausal women, 50 to 79 years old. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The main outcome was self-reported incident first fracture assessed prospectively by annual questionnaire. RESULT(S): The adjusted relative hazard (HR) for fracture among past OC users was 1.07 (95% CI, 1.01-1.15). Among women without any postmenopausal hormone treatment, past OC use for 5 years led to an HR of 1.09 (95% CI, 0.97-1.23) compared with never users. CONCLUSION(S): This study does not support the idea that past OC use protects against later fracture.

Topics

Contraception/Comparison > Side Effects > Hormonal ContraceptionBone Health > Osteoporosis Risk > PremenopausalPerimenopause/Menopause > Bone Health > Fracture Risk
oral contraceptive use bone health, birth control pill fracture risk postmenopause, past oral contraceptive use osteoporosis, hormonal contraception long-term bone effects, oral contraceptive history fracture outcomes, birth control pill menopause bone density, prior oc use postmenopausal fractures, contraceptive pill skeletal health later life

Cite this article

Barad, D., Kooperberg, C., Wactawski-Wende, J., Liu, J., Hendrix, S. L., & Watts, N. B. (2005). Prior oral contraception and postmenopausal fracture: a Women's Health Initiative observational cohort study. *Fertility and sterility*, *84*(2), 374-383. https://doi.org/10.1016/j.fertnstert.2005.01.132

Keywords

Aged, Cohort Studies, Confidence Intervals, Contraceptives, Oral, Estrogen Replacement Therapy, Female, Follow-Up Studies, Fractures, Bone, Hip Fractures, Humans, Middle Aged, Postmenopause, Prospective Studies, Risk Factors, Surveys and Questionnaires, United States, Women's Health

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