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Prevalence of hyperprolactinemia and thyroid disorders among patients with abnormal uterine bleeding

Abdel Hamid AM et al., 2015

Abdel Hamid AM, Borg TF, Madkour WA

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 131(3), 273-276, 2015

Source DOI PubMed

Abstract

Objective

To evaluate the prevalence of hyperprolactinemia and thyroid disorders among patients with abnormal uterine bleeding (AUB) compared with matched controls.

Methods

In 2013-2014, an observational study of women with AUB (group A) and women with regular menstruation (group B) was undertaken at one center in Egypt and one in the United Arab Emirates. Eligible women were aged 20-35 years and were not obese. Participants underwent clinical examinations, vaginal ultrasonography, office hysteroscopy (in selected cases), and measurement of hormone levels.

Results

Hyperprolactinemia was present in 17 (16.2%) of 105 patients in group A and 4 (3.2%) of 125 patients in group B (P=0.009). In group A, a high thyroid-stimulating hormone (TSH) level was observed in 8 (7.6%) patients and low levels of free triiodothyronine/thyroxine were found in 5 (4.8%) patients, compared with 2 (1.6%) patients and 1 (0.8%) patient in group B (P=0.012 and P=0.008, respectively). Polymenorrhea was the most frequent presentation of AUB (n=60 [57.1%]). Five (29.4%) patients with hyperprolactinemia had galactorrhea. In group A, 8 (47.1%) patients with a high TSH had hyperprolactinemia, whereas 1 (1.1%) patient with a high TSH had a normal prolactin value (P=0.008).

Conclusion

Screening by evaluating prolactin and thyroid hormone levels is recommended for all patients with AUB, even in the absence of galactorrhea.

Topics

Diagnostics > Hormone Assays > ProlactinDiagnostics > Hormone Assays > ThyroidReproductive Endocrinology > Prolactin > HyperprolactinemiaMenstrual Cycle > Disorders > Oligomenorrhea
abnormal uterine bleeding hormone screening, hyperprolactinemia menstrual disorders, thyroid dysfunction irregular bleeding, elevated prolactin polymenorrhea, tsh levels abnormal bleeding, root cause abnormal periods, galactorrhea hyperprolactinemia diagnosis, endocrine evaluation menstrual irregularity, hormone testing uterine bleeding, prolactin thyroid screening fertility, diagnostic workup anovulation, cross-sectional study menstrual cycle

Cite this article

Hamid, A. M. S. A., borg, T., & Madkour, W. A. I. (2015). Prevalence of hyperprolactinemia and thyroid disorders among patients with abnormal uterine bleeding. *International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics*, *131*(3), 273-276. https://doi.org/10.1016/j.ijgo.2015.05.035

Keywords

Adult, Case-Control Studies, Cross-Sectional Studies, Egypt, Female, Galactorrhea, Humans, Hyperprolactinemia, Menstruation Disturbances, Prevalence, Thyroid Diseases, Thyrotropin, Thyroxine, Triiodothyronine, United Arab Emirates, Uterine Hemorrhage, Abnormal Uterine Bleeding, Intermenstrual Bleeding, Menstruation, Thyroid

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