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Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea

Leyendecker G et al., 1980

The Journal of clinical endocrinology and metabolism, 51(5), 1214-1216

DOI 10.1210/jcem-51-5-1214 PMID 6775002 Source

Abstract

In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device ("Zyklomat") was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 50 microliters of a Gn-RH containing solution once every 90 minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.

Topics

Infertility > Female Factor > Ovulatory DysfunctionReproductive Endocrinology > Ovulation > InductionMenstrual Cycle > Disorders > Amenorrhea
pulsatile gnrh hypothalamic amenorrhea, gnrh pump infertility treatment, zyklomat device pregnancy induction, hypothalamic amenorrhea ovulation induction, intermittent gnrh administration pregnancy, portable gnrh pump outpatient treatment, restore ovarian function hypothalamic amenorrhea, pulsatile gonadotropin releasing hormone, absent gnrh secretion treatment, physiologic gnrh replacement infertility

Cite this article

Leyendecker, G., Wildt, L., & Hansmann, M. (1980). Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea. *The Journal of clinical endocrinology and metabolism*, *51*(5), 1214-1216. https://doi.org/10.1210/jcem-51-5-1214

Keywords

Adult, Amenorrhea, Chorionic Gonadotropin, Estradiol, Female, Follicle Stimulating Hormone, Gonadotropin-Releasing Hormone, Humans, Hypothalamus, Infertility, Injections, Intravenous, Luteinizing Hormone, Ovary, Pregnancy, Progesterone

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