Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy

Tulchinsky D, Hobel CJ, Yeager E, Marshall JR

doi:10.1016/0002-9378(72)90185-8

Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy

J R Marshall, C J Hobel, D Tulchinsky, E Yeager

UCLA Medical Center ROR
University of California, Los Angeles ROR

American Journal of Obstetrics and Gynecology, 112(8), 1095-1100

DOI 10.1016/0002-9378(72)90185-8 PMID 5025870

Abstract

To describe normal relationships between the various plasma unconjugated estrogens and progesterone during the second half of human pregnancy, the plasma concentrations of progesterone, 17-hydroxyprogesterone (17-OHP), and unconjugated estrone (E1), estradiol (E2), and estriol (E3) were measured in 126-310 normal women. Progesterone and unconjugated E1, E2, and E3 increased gradually throughout later pregnancy; 17-OHP increased only after the thirty-third week. At term the mean value of progesterone was 9 times higher than that 17-OHP. Throughout pregnancy the mean value of E2 was higher than that of E1 or E3. During the second half of pregnancy the ratios of progesterone to estradiol and estriol and of estradiol to estriol remained unchanged, indicating no preferential increase of plasma concentration of maternal or fetal hormones.

Topics

Reproductive Endocrinology > Steroid Hormones > Pregnancy Hormone Profiles Pregnancy > Normal Physiology > Hormonal Changes Diagnostics > Hormone Measurement > Pregnancy Reference Values

plasma estrogen progesterone normal pregnancy second half, Tulchinsky unconjugated estrogens pregnancy hormones, estrone estradiol estriol progesterone pregnancy levels, 17-hydroxyprogesterone normal pregnancy plasma concentrations, maternal hormone levels pregnancy estrogen progesterone ratio, fetal maternal steroid hormone production pregnancy, progesterone estradiol ratio normal pregnancy monitoring, unconjugated estriol plasma levels pregnancy term, pregnancy hormone reference values estrogen progesterone, second trimester third trimester steroid hormone concentrations

PMID 5025870 5025870 DOI 10.1016/0002-9378(72)90185-8 10.1016/0002-9378(72)90185-8

Cite this article

Tulchinsky, D., Hobel, C. J., Yeager, E., & Marshall, J. R. (1972). Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy. *American journal of obstetrics and gynecology*, *112*(8), 1095-1100. https://doi.org/10.1016/0002-9378(72)90185-8

Keywords

Estradiol/blood, Estriol/blood, Estrogens/blood, Estrone/blood, Female, Humans, Hydroxyprogesterones/blood, Pregnancy, Progesterone/blood, Protein Binding, Radioimmunoassay, Radioisotopes, Time Factors, Estrogens, Hydroxyprogesterones, Radioisotopes, Estrone, Progesterone, Estradiol, Estriol, Biology, Clinical Research, Endocrine System, Estrogens--analysis, Hematological Effects, Hemic System, Hormones, Physiology, Pregnancy, Progestational Hormones, Progesterone--analysis, Reproduction, Research Methodology

Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy

Abstract

Topics

Cite this article

Keywords

Related articles

Incident endometriosis diagnosis and anti-müllerian hormone (AMH): how surgical staging and typology relate to serum AMH levels

"Uterine closure after cesarean delivery: surgical technique, biological rationale, and clinical implications."

Prevalence and risk factors for postpartum depression 2 months after a vaginal delivery: a prospective multicenter study

Placental histology for targeted risk assessment of recurrent spontaneous preterm birth