Data from the Oxford.FPA prospective study show that oral contraceptive use and pregnancy have no discernible effect on the risk of developing multiple sclerosis (MS). Women of parity 0-2 developed MS twice as often as women of parity 3 or more but the difference did not reach statistical significance. Smoking may be a risk factor for developing MS. A nested case-control analysis did not identify any associations between MS onset and preceding illnesses.
PMID 8449016 8449016 DOI 10.1016/0010-7824(93)90088-o 10.1016/0010-7824(93)90088-o
Cite this article
Villard-Mackintosh L, & Vessey, M. (1993). Oral contraceptives and reproductive factors in multiple sclerosis incidence. *Contraception*, *47*(2), 161-168. https://doi.org/10.1016/0010-7824(93)90088-o
Villard-Mackintosh L, Vessey M. Oral contraceptives and reproductive factors in multiple sclerosis incidence. Contraception. 1993;47(2):161-168. doi:10.1016/0010-7824(93)90088-o
Villard-Mackintosh L, and Martin Vessey. "Oral contraceptives and reproductive factors in multiple sclerosis incidence." *Contraception*, vol. 47, no. 2, 1993, pp. 161-168.
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