Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium
M Breuiller, L Cedard, F Ferre, Y Janssens, A Jolivet, C Sureau, G Tanguy, M Uzan
A single dose of micronized oral progesterone was administered to 15 pregnant women immediately prior to elective cesarean section. Levels of progesterone, 17 beta-estradiol, and estrone were measured in the plasma, in the placenta, and at different sites in myometrium obtained during the surgical procedure. Results were compared to those observed in a control group of women who did not receive progesterone. Progesterone levels demonstrated a marked increase in plasma and in the whole myometrium 150 minutes after administration. The levels then decreased rapidly to control values in 1 hour. The concentrations of progesterone in the placenta did not show any changes. No difference appeared in 17 beta-estradiol levels in the plasma or the myometrium, whereas an increase was observed in the placenta. Estrone levels did not change in the plasma, but they decreased in the myometrium and in the placenta.
PMID 6691378 6691378 DOI 10.1016/s0002-9378(84)80027-7 10.1016/s0002-9378(84)80027-7
Cite this article
Ferre, F., Uzan, M., Janssens, Y., Tanguy, G., Jolivet, A., Breuiller, M., Sureau, C., & Cedard, L. (1984). Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium. *American journal of obstetrics and gynecology*, *148*(1), 26-34. https://doi.org/10.1016/s0002-9378(84)80027-7
Ferre F, Uzan M, Janssens Y, Tanguy G, Jolivet A, Breuiller M, et al. Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium. Am J Obstet Gynecol. 1984;148(1):26-34. doi:10.1016/s0002-9378(84)80027-7
Ferre, F., et al. "Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium." *American journal of obstetrics and gynecology*, vol. 148, no. 1, 1984, pp. 26-34.
Valenti M et al., 2026American journal of obstetrics and gynecology
Background: Endometriosis is a chronic, gynecologic condition in which tissue similar to the lining of the uterus implants throughout the body. Women with endometriosis have a higher prevalence of inf...
Bujold E et al., 2026American Journal of Obstetrics and Gynecology
Normal uterine function depends on cyclical regeneration and the capacity to sustain pregnancy. A cesarean incision represents an injury to this remarkable organ. Although the uterus possesses excepti...
Froeliger A et al., 2024American Journal of Obstetrics and Gynecology
Background: Very little is known about the prevalence and risk factors of postpartum depression among women with vaginal births without major pregnancy complications.
Objective: This study aimed to a...
Suresh S et al., 2023American Journal of Obstetrics and Gynecology
Background: Spontaneous preterm birth significantly increases the risk for a recurrent preterm birth. Only a few identifiable clinical risk factors can be referenced in counseling for recurrent preter...