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Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium

Ferre F et al., 1984

American journal of obstetrics and gynecology, 148(1), 26-34

DOI 10.1016/s0002-9378(84)80027-7 PMID 6691378 Source

Abstract

A single dose of micronized oral progesterone was administered to 15 pregnant women immediately prior to elective cesarean section. Levels of progesterone, 17 beta-estradiol, and estrone were measured in the plasma, in the placenta, and at different sites in myometrium obtained during the surgical procedure. Results were compared to those observed in a control group of women who did not receive progesterone. Progesterone levels demonstrated a marked increase in plasma and in the whole myometrium 150 minutes after administration. The levels then decreased rapidly to control values in 1 hour. The concentrations of progesterone in the placenta did not show any changes. No difference appeared in 17 beta-estradiol levels in the plasma or the myometrium, whereas an increase was observed in the placenta. Estrone levels did not change in the plasma, but they decreased in the myometrium and in the placenta.

Topics

Reproductive Endocrinology > Progesterone > SupplementationPregnancy > Outcomes > ComplicationsDiagnostics > Hormone Assays > Progesterone
micronized progesterone pregnancy, oral progesterone late pregnancy, progesterone pharmacokinetics third trimester, progesterone levels placenta myometrium, progesterone administration cesarean section, natural progesterone bioavailability pregnancy, progesterone tissue distribution late pregnancy, micronized progesterone dosing third trimester, progesterone supplementation before delivery, progesterone plasma levels pregnancy, estradiol changes progesterone administration, myometrial progesterone concentrations

Cite this article

Ferre, F., Uzan, M., Janssens, Y., Tanguy, G., Jolivet, A., Breuiller, M., Sureau, C., & Cedard, L. (1984). Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium. *American journal of obstetrics and gynecology*, *148*(1), 26-34. https://doi.org/10.1016/s0002-9378(84)80027-7

Keywords

Administration, Oral, Cesarean Section, Estradiol, Estrogens, Estrone, Female, Humans, Myometrium, Obstetric Labor, Premature, Placenta, Pregnancy, Progesterone

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