0 Ask Beta Account

Noxytiolin and peritoneal adhesion formation

C Reid, O J A Gilmore

  • St Bartholomew's Hospital ROR

The British Journal of Surgery, 63(12), 978-980

DOI 10.1002/bjs.1800631224 PMID 1034491

Abstract

Clinical and experimental studies have suggested that intraperitoneal noxytiolin prevents adhesion formation. A reliable experimental animal model was therefore established and the effect of noxytiolin on adhesion formation was evaluated in a controlled trial using 80 rats. All 40 rats given Ringer solution developed adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P less than 0-02). Noxytiolin reduced both the total and the mean number of adhesions formed (P less than 0-2) and their mean length of attachment (P less than 0-05). The anti-adhesive effect of noxytiolin may be due to its anticoagulant, cytotoxic or antibacterial properties.

Topics

Surgery > Adhesion Prevention > Intraperitoneal AgentsResearch Methodology > Animal Models > Controlled Trials
noxytiolin peritoneal adhesion prevention, intraperitoneal noxytiolin adhesion formation rat model, peritoneal adhesion prevention antiseptic agent, noxytiolin anti-adhesive effect controlled trial, postoperative adhesion prevention intraperitoneal agent, noxytiolin anticoagulant antibacterial adhesion reduction, peritoneal adhesion animal model experimental surgery, adhesion prevention surgical intervention Ringer solution control, postoperative peritoneal adhesion prophylaxis experimental, Gilmore Reid noxytiolin adhesions British Journal Surgery
PMID 1034491 1034491 DOI 10.1002/bjs.1800631224 10.1002/bjs.1800631224

Cite this article

Gilmore, O. J., & Reid, C. (1976). Noxytiolin and peritoneal adhesion formation. *The British journal of surgery*, *63*(12), 978-980. https://doi.org/10.1002/bjs.1800631224

Keywords

Animals, Disease Models, Animal, Female, Injections, Intraperitoneal, Noxythiolin/administration & Dosage/therapeutic Use, Peritoneal Diseases/etiology/prevention & Control, Peritoneum/surgery, Rats, Thiourea/analogs & Derivatives, Tissue Adhesions, Noxythiolin, Thiourea